Each 1ml contains:
Sulfadiazine 150 mg
Neomycin (as Neomycin Sulfate) 25 mg
Sulfadiazine is a broad spectrum antimicrobial agent. It acts by interfering with the biosynthesis of folic acid in bacterial cells, competitively preventing para-amino benzoic acid (PABA) from incorporation into the folic acid molecule. It is rapidly absorbed from the gastrointestinal tract and widely distributed to all tissues and body fluids. The sulphonamides are eliminated by a combination of renal excretion and biotransformation.
Neomycin is the isomeric mixture of Neomycin B and C. It has a rapid dose related bactericidal action on susceptible microorganisms. The antibacterial action is directed primarily against aerobic gram negative bacteria. It is poorly absorbed from the gastrointestinal tract, has a short life and is nearly all excreted unchanged in the faeces.
For the treatment of:
– Diarrhea in pre-ruminant calves associated with infections caused by organisms known to be, or
suspected of being, susceptible to the combination of sulfadiazine and neomycin.
Pre-ruminant calves.
Orally
-Shake well before use.
-For whole product : 4 ml of product / 10 kg. b. wt. twice daily.
-The maximum period of treatment is 5 days.
– The product is intended for use in calves only. Do not use in lactating cows.
– Concurrent intravenous fluid therapy should be considered in dehydrated calves.
– Parenteral antibiotic treatment should be considered if a clinical response is not seen after 48 hours treatment
– Use of the product should be based on susceptibility testing of the bacteria isolated from the animal. If this is not possible, therapy should be based on local (regional, farm level) epidemiological information about susceptibility of the target bacteria.
– Avoid contact with skin.
– Wash hands after use.
– Do not use in animals with known hypersensitivity to the active ingredients.
– Do not exceed the recommended dosage or the period of treatment.
– Do not use local anaesthetics of the procaine group during treatment as they are antagonistic to the sulphonamide component.
– Do not use in calves with functional rumens.
– Do not use in lactating cows.
– Do not use in foals and horses.
– There is interaction and antagonism between sulphonamides and the Vitamin B Complex. Do not use –local anaesthetics of the procaine group during treatment, as they are antagonistic to the sulphonamide component.
– Chronic usage of oral neomycin may result in bacterial or fungal superinfections.
– Good tolerance has been confirmed in calves at x3 and x5 the recommended dose rate.
Meat & offal: 28 days.
Not intended for use in animals producing milk for human consumption.
Store at a temperature not exceeding 30°C.
Opaque white (HDPE) Plastic bottle Contain 20,25,50,75,100, 200, 250, 500, 750, 1000 ml Oral Solution lined with red (HDPE) Plastic Film and aluminum seal closed by white Plastic (HDPE) cap with (LDPE) inner foam liner with an outer label without insert