Composition:

Each 1ml contains :
Moxidectin 1 mg
Triclabendazole 50 mg

Properties:

Moxidectin is an endectocide active against a wide range of internal and external parasites and is a second generation macrocyclic lactone of the milbemycin family. Its principal mode of action is interfering with neuromuscular transmission of the GABA (gamma amino butyric acid)-gated or glutamate-gated chloride channels. Moxidectin stimulates the release of GABA and increases its binding to the postsynaptic receptors, and binds to the glutamate-gated chloride channels. The net effect is to open the chloride channels on the postsynaptic junction to allow the inflow of chloride ions and induce an irreversible resting state. This results in flaccid paralysis and eventual death of parasites exposed to the drug. Triclabendazole is a flukicide belonging to the benzimidazole group of anthelmintics. It is well established that benzimidazole anthelmintics selectively bind to β-tubulin, thus causing the depolymerisation of microtubules and the subsequent disruption of microtubule-based processes in helminths

Indications:

It is used for treatment of:
Mixed nematode and fluke infections, caused by moxidectin and triclabendazole sensitive strains of:
• Parasite Adult stage L4 Inhibited stages
• Nematodes
• Gastro-intestinal nematodes:
• Haemonchus contortus
• Teladorsagia circumcincta
• Ostertagia trifurcata
• Trichostrongylus axei
• Trichostrongylus colubriformis
• Trichostrongylus vitrinus
• Nematodirus battus
• Nematodirus spathiger
• Nematodirus filicolis
• Strongyloides papillosus
• Cooperia curticei
• Cooperia oncophora
• Oesophagostomum columbianum
• Oesophagostomum venulosum
• Chabertia ovina
• Trichuris ovis
• Respiratory tract nematode:
• Dictyocaulus filaria
• Trematodes
• Liver fluke: Adult stage Early Immature stages Late Immature.

Target Species:

Sheep.

Dosage & Route of administration:

Route of administration: orally via drinking water .
For active ingredient: 0.2 mg moxidectin/ kg.b.wt.+ 10 mg triclabendazole/kg.b.wt.
For whole product: 1 ml of product/5 kg.b.wt.
– Don’t retreat animal for 70 days (10 weeks) after last treatment

Warnings:

• Suspected clinical cases of resistance to anthelmintics should be further investigated using appropriate tests (e.g. Faecal Egg Count Reduction Test). Where the results of the test(s) strongly suggest resistance to a particular anthelmintic, an anthelmintic belonging to another pharmacological class and having a different mode of action should be used.

Contra-indications:

-Do not administer to animals with known hypersensitivity to the active ingredients.

Adverse effects :

None known

Withdrawal Periods:

Meat and offal: 31 days
Milk: not authorized for use in ewes producing milk intended for human consumption including during the dry period. Do not use within 1 year prior to the first lambing in ewes intended to produce milk for human consumption.

Storage conditions:

Store at a temperature not exceeding 30°C

Packaging:

100, 250, 500 and 1000 ml of the product in white HDPE plastic bottle closed by opaque HDPE white screw cap lined with HDPE plastic film with outer label without Insert