Composition:

Each 100 gm contains:
Neomycin (as Sulphate) 14 gm

Properties:

Neomycin is an antibiotic from the aminoglycoside family. Aminoglycosides have a broad antibacterial spectrum with good activity against Gram negative bacteria (E.coli, Salmonella spp,Klebsiella spp,Pseudomonas aerugenosa, Bordetella bronchiseptica, pasteurella spp) and less activity against Gram positive bacteria Staphylococcus aureus This class of antimicrobials has no effect against anaerobic bacteria. Neomycin binds to the 30S subunit of the bacterial ribosome which disturbs the reading of the constituent code of the RNA messenger, and finally the synthesis bacterial protein. At high concentrations, it has been shown that aminoglycosides damage the cell wall, conferring bactericidal and bacteriostatic properties.

Indications:

For treatment it is used of:
Pre-ruminating calves : Scours caused by E. coli.
pigs (weaned and fattening pigs):Enteric Colibacillosis caused by E. coli.
Brolier chickens and Turkeys for meat production: Intestinal Colibacillosis caused by E. coli.

Target Species:

Pre-ruminating calves , pigs (weaned and fattening pigs), Brolier chickens and Turkeys for meat production

Dosage & route of administration:

Route of administration: Orally in drinking water in pigs (weaned and fattening pigs), Brolier chickens and Turkeys for meat production and milk replacer for Pre-ruminating calves.
Dose of Active ingredient:
• Pre-ruminating calves, pigs (weaned and fattening pigs): 10 to 15 mg of neomycin per kg of bodyweight every 12 hours for 3 to 5 consecutive days.
• Brolier chickens, Turkeys for meat production: 20 to 30 mg of neomycin per kg of bodyweight per day for 3 to 5 consecutive day.
Dose of Whole product:
• Pre-ruminating calves, pigs (weaned and fattening pigs): 1.8 to 2.7 g of powder per 25 kg of bodyweight every 12 hours for 3 to 5 consecutive days.
• Brolier chickens, Turkeys for meat production: 1.43 to 2.14 g of powder per 1 liters of drinking water per day for 3 to 5 consecutive days.

Special warnings for each target species:

• Medicated drinking water intake can be affected by the severity of the disease. In case of insufficient intake of water/milk replacer, calves and pigs should be treated parenterally.

Special precautions for use:

Special precautions for use in animals:
• Powder for oral solution that is to be dissolved in water and cannot be used as it is.
• Special care should be taken when considering administration of the product to the newborn calf due to the known higher gastrointestinal absorption of neomycin in neonates. This higher absorption could lead to an increased risk of oto- and nephrotoxicity.
• The use of the product in neonates should be based on the benefit/risk determination from the attending veterinarian.
• Use of the product should be based on susceptibility testing of the bacteria isolated from the animal. If this is not possible, therapy should be based on local (regional, farm level) epidemiological information about susceptibility of the target bacteria.
• Use of the product deviating from the instructions given in the label may increase the prevalence of bacteria resistant to neomycin and may decrease the effectiveness of treatment with aminoglycosides due to the potential for cross-resistance.
Special precautions to be taken by the person administering the veterinary medicinal product to animals:
• Wash hands after use.
• People with known hypersensitivity to aminoglycosides should avoid contact with the veterinary medicinal product.
• If you develop symptoms following exposure such as a skin rash, you should seek medical advice and show the doctor this
• warning. Swelling of the face, lips or eyes or difficulty with breathing are more serious symptoms and require urgent medical attention.
Use during pregnancy, lactation or lay:
• Laboratory studies in animals have not produced any evidence of teratogenic effects of neomycin.
• The safety of the veterinary medicinal product has not been established during pregnancy, lactation or lay in the target species.
• Use only according to the benefit/risk assessment by the responsible veterinarian.

Contra-indication:

• Do not use in known cases of hypersensitivity to the active substance, to aminoglycosides or to any of the excipients.
• Do not use in cases of intestinal obstruction.

Drug–drug interaction:

• General anaesthetics and muscle relaxing products increase the neuro-blocking effect of aminoglycosides. This may cause paralysis and apnoea.
• Special care should be taken when using concurrently with diuretics and potentially oto- or nephrotoxic substances.

Side effects:

None known.

Overdose (symptoms, emergency procedures, antidotes), if necessary:

Nephrotoxic and/or ototoxic effects may occur in case of accidental overdose.

Withdrawal Period(s):

• Pre-ruminating calves, pigs (weaned and fattening pigs): Meat and offal: 14 days.
• Brolier chickens, Turkeys for meat production: Meat and offal: 14 days

Storage conditions:

• Store at temperature not more than 30°C
• Used immediately after opening & after reconstitution.
• Keep out from reach of children.

Packagings:

100,250,500 and1000 gm plastic jar.