Martiroflox 16 %
Martinix
Martisolcom
Solution For Injection
Composition :
Each ml contains
Marbofloxacin 160 mg
Properties:
Marbofloxacin is a synthetic, bactericidal antimicrobial, belonging to the fluoroquinolone group, which acts by inhibition of DNA gyrase. The in vitro activity of marbofloxacin has been demonstrated towards Pasteurella multocida, Mannheimia haemolytica and Escherichia coli.
Resistance to fluoroquinolones occurs by chromosomal mutation with three mechanisms: decrease of the bacterial wall permeability, expression of efflux pump or mutation of enzymes responsible for molecule binding.
Indications:
- In cattle: Treatment of respiratory infections caused by sensitive strains of Pasteurella multocida and Mannheimia haemolytica.
In lactating cows: Treatment of acute mastitis caused by sensitive strains of Escherichia coli.
Target Species:
Cattle.
Dosage& route of administration:
By IM or IV injection
For active ingredient:
Cattle : 10 mg per kg by IM or IV Injection
Dose for whole product:
Cattle : 10 ml of product per 160 kg body weight
Warnings:
- Don’t use in Domestic animals neonates
- Official and local antimicrobial policies should be taken into account when this product is used.
- Fluoroquinolones should be reserved for the treatment of clinical conditions which have responded poorly, or are expected to respond poorly, to other class of antimicrobials. Wherever possible, use of the product should only be based on susceptibility testing.
- Use of the product deviating from the instructions given in this SPC may increase the prevalence of bacteria resistant to the fluoroquinolones and may decrease the effectiveness of treatment with other quinolones due to the potential for cross resistance.
Contra-indications
- Do not use in animals with known hypersensitivity to fluoroquinolones or to any of the excipients.
- Do not use in cases where the pathogen involved is resistant to other fluoroquinolones (cross resistance).
Side-Effects:
Administration by the intramuscular route may cause rare transient local reactions such as pain and swelling at the injection site which may persist up to 7 days after injection.
Fluoroquinolones are known to induce arthropathies. In cattle, such lesions were observed after a three days treatment with the 16% marbofloxacin solution. These lesions did not induce clinical signs and should be reversible, particularly if they were to be observed after a single administration.
No other adverse effect was observed on cattle
Withdrawal Periods:
Meat and offal: 5 days
Milk: 2 days
Storage conditions:
Store in dry dark and place at temperature not exceeding to 30 o.
Packaging:
Vial of 50,100 and 250 ml.
