Moximartiro 10 % inj
Martisolcom
Moximartiro
Solution For Injection
Composition :
Each ml contains
Moxidectin 100 mg
Properties:
Moxidectin is an endectocide active against a wide range of internal and external parasites and is a second generation macrocyclic lactone of the milbemycin family.
Moxidectin interacts with GABA receptors and chloride channels.
The net effect is to open the chloride channels on the postsynaptic junction to allow the inflow of chloride ions and induce an irreversible resting state. This results in flaccid paralysis and eventual death of parasites exposed to the drug.
Moxidectin is absorbed following subcutaneous injection with maximum blood concentrations being achieved 24 to 48 hours post injection. The drug is distributed throughout the body tissues but due to its lipophilicity it is concentrated mainly in the fat. The depletion half-life in fat is 26 – 32 days.
Moxidectin undergoes limited biotransformation by hydroxylation in the body. The only significant route of excretion is the faeces
Indications:
In cattle weighing from 100 to 500 kg body weight
Treatment and prevention of mixed infestations by the following gastro-intestinal nematodes, respiratory nematodes and certain arthropod parasites:
Adult and immature gastro-intestinal nematodes: ( Haemonchus placei , Haemonchus contortus , Ostertagia ostertagi (including inhibited larvae) , Trichostrongylus axei, Trichostrongylus colubriformis , Nematodirus helvetianus (adults only), Nematodirus spathiger , Cooperia surnabada, Cooperia oncophora,Cooperia pectinata , Cooperia punctate, Oesophagostomum radiatum , Bunostomum phlebotomum (adults only), Chabertia ovina (adults only) and Trichuris spp. (adults only) )
Adult and immature respiratory tract nematode : Dictyocaulus viviparus
Warble grubs (migrating larvae) : Hypoderma bovis and Hypoderma lineatum
Lice: Linognathus vituli ,Haematopinus eurysternus , Solenopotes capillatus and Bovicolabovis (aid in control)
The drug has a persistent action and protects cattle for a certain duration against infection or re-infection with the following parasites for the period indicated:
Species Protection period (days)
Dictyocaulus viviparus 120
Ostertagia ostertagi 120
Haemonchus placei 90
Oesophagostomum radiatum 150
Trichostrongylus axei 90
Linognathus vituli 133
The product is effective against Hypoderma larvae at the time of treatment but its persistent activity against Hypoderma has not been evaluated.
If the product is given before the end of the fly season complimentary treatment with a product effective against Hypoderma may be required.
Target Species:
Cattle.
Dose for active ingredient:
given by a single subcutaneous injection in the ear
Cattle : 1.0 mg moxidectin/kg bodyweight
Dose for whole product:
Cattle : 0.5 ml/50 kg bodyweight
Warnings & precautions:
- Care should be taken to avoid the following practices because they increase the risk of development of resistance and could ultimately result in ineffective therapy.
- Too frequent and repeated use of anthelmintics from the same class, over an extended period of time
- Underdosing, which may be due to underestimation of body weight, misadministration of the product, or lack of calibration of the dosing device (if any).
- Suspected clinical cases of resistance to anthelmintics should be further investigated using appropriate tests (e.g. Faecal Egg Count Reduction Test). Where the results of the test(s) strongly suggest resistance to a particular anthelmintic, an anthelmintic belonging to another pharmacological class and having a different mode of action should be used.
Contra-indications
Do not use in cattle less than 100 kg bodyweight or greater than 500 kg.
Do not use in cases of hypersensitivity to the active substance or to any of the excipients.
Side-Effects:
Immediate or delayed swelling may be found at the injection site. On rare occasions (approx 1%), these swellings may further develop into abscesses. The frequency of injection site swellings tends to be higher in the heavier animals. The side effects generally disappear, without treatment, within 14 days of administration, some may persist for up to 5 weeks in a number of animals (<5%) and in very rare occasions longer.
On rare occasions, depression and ataxia can be observed after injection.
Withdrawal Periods:
Meat and offal: 108 days.
Milk: Not permitted for use in lactating animals producing milk for human consumption or industrial purposes or within 80 days of expected parturition.
Storage:
Store in dry dark and place at temperature not exceeding to 30 o.
Packaging:
Vial of 50,100 and 250 ml.
