Maroliz
Martidex
Sterile powder and solvent for Solution for injection
(For vet. use only)
Composition :
Each Vial contains ceftiofur (as sodium ceftiofur) 1 g
Each ml of reconstituted solution contains ceftiofur 50 mg.
Properties:
Sodium ceftiofur, a broad spectrum cephalosporin which is active against Gram-positive and Gram-negative bacteria, including beta-lactamase producing strains.
Ceftiofur has bactericidal activity in vitro. The mode of action is that of cephalosporins, i.e.
inhibition of the bacteria cell wall synthesis.
Indications:
Cattle:
treatment of bovine bacterial respiratory disease associated with Mannheimia haemolytica, Pasteurella multocida, and Actinobacillus (Haemophilus) somnus and other sensitive bacterial pathogens.
For the treatment of cattle with acute interdigital necrobacillosis (foul in the foot) in which Fuosbacterium necrophorum and Bacteroides melaninogenicus are involved.
Pigs :
The treatment of pigs with bacterial respiratory disease in which Actinobacillus (Haemophilus) pleuropneumonia, Pasteurella multocida and Streptococcus suis are involved.
Horses:
For the treatment of horses with bacterial respiratory disease associated with Streptococcus spp. (including Streptococcus zooepidemicus), Staphylococcus spp. and/or Pasteurella spp.
Target Species:
Cattle, pigs and horses.
Dosage of administration:
Route: Dissolve the 1 g sterile powder in 20 ml of Water for Injection.
The resulting solution contains 50 mg ceftiofur free acid equivalents per ml. The reconstituted product is to be administered intramuscularly. For ease of reconstitution use an 18 gauge needle
For active ingredient:
Cattle:
1 mg/kg bodyweight
For respiratory disease, the dose should be given once daily at 24 hour intervals for 3 to 5 days in total.
For interdigital necrobacillosis (foul in the foot), the dose should be given once daily at 24 hour intervals for 3 days.
Pigs:
3 mg/kg bodyweight: The dose should be given once daily at 24 hour intervals for 3 days.
Horses:
2 mg/kg bodyweight: The dose should be given once daily at 24 hour intervals and continued for 48 hours after clinical signs have disappeared. A 10-day treatment period is usually adequate. A maximum of 10 ml solution should be administered per injection site.
If no response is seen within 4-5 days, the diagnosis should be re-determined.
For whole product:
Cattle:
1 ml of the reconstituted solution per 50 kg bodyweight.
For respiratory disease, the dose should be given once daily at 24 hour intervals for 3 to 5 days in total.
For interdigital necrobacillosis (foul in the foot), the dose should be given once daily at 24 hour intervals for 3 days.
Pigs:
1 ml of the reconstituted solution per 16 kg bodyweight.
The dose should be given once daily at 24 hour intervals for 3 days.
Horses:
2 ml of the solution per 50 kg bodyweight. The dose should be given once daily at 24 hour intervals and continued for 48 hours after clinical signs have disappeared. A 10-day treatment period is usually adequate. A maximum of 10 ml solution should be administered per injection site.
If no response is seen within 4-5 days, the diagnosis should be re-determined.
Warning & precautions:
The administration of antimicrobials to horses under conditions of stress may be associated with acute diarrhoea, which could be fatal. If acute diarrhoea is observed, discontinue use of this antimicrobial and initiate appropriate therapy.
No data available for cattle.
Rapid addition of diluent will give best results.
The intramuscular route only should be used in cattle, pigs and horses.
Contra-indications
As for all antibiotics, do not administer to animals previously found to be hypersensitive to the active ingredient.
Do not use in poultry (including eggs) due to the risk of spread of antimicrobial resistance to humans
Adverse Effects:
General symptoms are not detected. The use of ceftiofur sodium may result in some signs of immediate and short lasting pain at the site of injection.
Withdrawal time:
Meat:
Cattle – 1 day
Pigs – 2 days
Milk:
Cattle – zero hours
Not for use in horses intended for human consumption.
Treated horses may never be slaughtered for human consumption.
The horse must have been declared as not intended for human consumption under national horse passport legislation
Storage conditions:
At temperature not exceeding 30◦c and to be used immediately after opening.
Packaging:
Cardboard carton containing one Type 1 glass vial containing 1 g of product, closed with a butyl rubber closure and aluminium cap. and 20 ml of water for injection as a Solvent
