Martivetlox
Martiroflox 2%
Solution for injection
For vet. use only
Indications:
For treatment of the following parasites by cattle and pig:
Cattle:
Gastro-intestinal roundworms (adult and fourth stage larvae, L4):
Ostertagia ostertagi (including inhibited L4), Ostertagia lyrata, Haemonchus placei, Trichostrongylus axei, Trichostrongylus colubriformis (L4), Cooperia oncophora, Cooperia punctata, Cooperia pectinata
Nematodirus spatiger (adult) & Oesophagostomum radiatum
Lungworms (adult and fourth stage larvae, L4): Dictyocaulus viviparus
Warbles (larval stages): Hypoderma bovis & Hypoderma lineatum
Mange Mites: Sarcoptes scabiei var. bovis & Psoroptes bovis
Lice: Linognathus vituli & Haematopinus eurysternus
Pig:
Gastro-intestinal roundworms (adult and fourth stage larvae, L4):
Ascaris suum, Hyostrongylus rubidus, Oesophagostomum spp., Strongyloides ransomi (adult)
Lungworms: Metastrongylus spp. (adult)
Mange Mites: Sarcoptes scabiei var. suis
Lice: Haematopinus suis
Target Species:
Cattle (Excluding dairy cows), pigs.
Dosage of administration:
Route: To be administered by subcutaneous injection.
For active ingredients:
Cattle (Excluding dairy cows): 0,2 mg ivermectin per kg body weight injected subcutaneously. once daily in a single dose
Pig: 0,3 mg ivermectin per kg body weight injected subcutaneously., once daily in a single dose.
Dose for whole product:
Cattle (Excluding dairy cows): 1 mL per 50 kg body weight, once daily in a single dose.
Pig: 1 ml per 33 kg body weight,, once daily in a single dose.
Composition :
Each 1 ml contains:
Ivermectin 10 mg
Properties:
Ivermectin is a member of the macrocyclic lactone class of endectocides which have a unique mode of action. Compounds of this class bind selectively and with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve and muscle cells. This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the parasite. Compounds of this class may also interact with other ligandgated chloride channels, such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA).
The margin of safety for compounds of this class is attributable to the fact that mammals do not have glutamate-gated chloride channels, the macrocyclic lactones have a low affinity for other mammalian ligand-gated chloride channels and they do not readily cross the blood-brain barrier.
Ivermectin act against Gastro-intestinal roundworms (adult and fourth stage larvae, L4), Lungworms (adult and fourth stage larvae, L4), Warbles (larval stages), Mange Mites and Lice.
Warnings and Precautions:
- Neonatal pigs are sensitive for overdosing of ivermectin, probably because of a higher permeability of the blood-brain-barrier.
- Piglets < 5 days should not be injected.
- In non-target species, ivermectins / milbemycins can be less well tolerated. (Cases of intolerance with fatal consequences have been reported in dogs, particularly collies, Old English Sheepdogs and related breeds and turtles).
- The product can be administered to beef cows and pigs at any stage of pregnancy or lactation.
- To avoid secondary reactions due to the death of Hypoderma larvae in the oesophagus or in the spine it is recommended to administer the product at the end of warble fly activity and before the larvae reach their resting sites. Consult your veterinarian on the correct timing of treatment.
- Do not use in new-born domestic animals. … This product contains benzyl alcohol which has been documented to cause adverse reactions in neonates.
Contra-indications
- Do not use in case of hypersensitivity to the active substance or to any of the excipients.
- Do not administer by the intravenous or intramuscular route.
- Do not use in dogs or cats.
- Do not use in lactating cows producing milk for human consumption.
- Do not use in cattle producing milk for human consumption or in dairy cows within 60 days prior to calving.
Adverse Effects:
- Cattle
Transitory discomfort has been observed in some cattle following subcutaneous administration. A low incidence of soft tissue swelling at the injection site has been observed. These reactions have disappeared without treatment. - Pigs
Mild and transient pain reactions may be seen in some pigs following subcutaneous injection.
All these reactions disappeared without treatment.
Withdrawal time:
Cattle (Excluding dairy cows): Meat and offal: 49 days.
Pigs: Meat and offal: 28 days.
Storage conditions:
At temperature not exceeding 30◦C and to be used immediately after opening.
Packaging:
Clear colorless glass type II of 20, 50, 100 ml.
Manufactured by Badr Pharma for Martiros for pharmaceutical industries
