Solution For Injection

For Veterinary Use Only

Composition:

Each 1 ml contains:
Chlorphenamine maleate 10 mg
(Equivalent to 7.03 mg chlorphenamine)

Properties:

Chlorphenamine maleate is a racemic compound classified as an antihistamine from the group of alkyl amine that, due to its chemical characteristics, is able to bind to the H1receptor present on the cell membrane and therefore compete with the natural endogenous ligand for the same site. Receptor occupation by chlorphenamine maleate does not, in itself, induce pharmacological responses, but significantly inhibits those induced by histamine. On the basis of these observations, chlorphenamine maleate behaves as a direct or reversible competitive receptor antagonist. Chlorphenamine maleate is not able to inhibit the synthesis or release of histamine.
10.2 mg nitroxynil/kg bw) it is effective against sensitive strains of the internal and external parasites.

Indications:

For the symptomatic treatment of conditions associated with histamine release.

Target species:

Cattle.

Dosage & Administration:

Route: I/M or I/V.
-Intravenous injection should be slow and, if necessary, discontinued for a few Minutes.
For whole product:
Adult animals (Cattle): 5 ml/100 kg.b.wt. Once a day for three consecutive days.
Calves: 10 ml/100 kg .b.wt. Once a day for three consecutive days.

Warning & precautions:

-Although intravenous administration has an immediate therapeutic effect, it can have excitatory effects on the CNS. Consequently, administer slowly and interrupt administration for a few minutes if necessary, when using this route.
-Precautions should be taken to avoid accidental self-injection with this drug.
-Preferably use a guarded needle until the moment of injection.
-In case of accidental self-injection, seek medical advice immediately and show the package leaflet or the label to the physician.
-The safety of the product during pregnancy and lactation has not been established.
– Concomitant use of other antihistamines or barbiturates may boost the sedative effect of chlorphenamine. The use of antihistamines may conceal early signs of ototoxicity caused by some antibiotics (i.e. aminoglycosides and macrolides) and may shorten the effect of oral anticoagulants.

Contra – Indications:

– Do not use in cases of hypersensitivity to the active substance or to any of the excipients.
-Never administer via the subcutaneous route.
– In the absence of compatibility studies, this veterinary medicinal product must not be mixed with other medicinal products.

Side-Effects:

-Chlorphenamine has a weak sedative effect.
-In very rare cases, local reactions were observed at the injection site. All the reactions were transient and resolved spontaneously.
-Use only accordingly to the benefit-risk assessment by the responsible veterinarian

Withdrawal Time:

Meat and offal: 1 day
Milk: 12 hours

Storage conditions:

Store at temperature not exceeding 30°C and used immediately after opening

Packaging:

Carton Box contains Colorless glass ( Type II ) vials containing
15 and100 ml solution closed with bromobutyl rubber stopper and non-re-usable aluminum closures with an outer label and insert Leaflet.