Cilloclav
Apramart 100%
Doppio colineo
Composition :
Each 1gm contains:
Amoxicillin 500 mg
(corresponding to 573.88 mg of Amoxicillin trihydrate)
Clavulanic acid 125 mg
(corresponding to 148.88 mg of Potassium clavulanate)
Properties:
The product is a combination of a β-lactam antibiotic with a β¬lactamase inhibitor which restores the potency of amoxicillin against strains producing β¬lactamases.
Amoxicillin is a bactericidal antibiotic, which acts by inhibiting the synthesis of bacterial cell walls during bacterial multiplication. It inhibits cross-linkage between the linear peptidoglycan polymer chains in the cell wall of Gram-positive bacteria as (Clostridium perfringens., Streptococcus suis. ). Broad spectrum penicillin antibiotic amoxicillin is active also against a limited range of Gram negative bacteria as (Pasteurella, E. coli, Salmonella typhimurium). where the outer layer of bacteria cell-wall is made up of lypopolysaccharide and protein.
Clavulanic acid acts as inhibitor of bacterial β-lactamases. It prevents destruction of the β-lactam ring and penicillins by β-lactamase enzymes. The reaction is irreversible and both the enzyme and the clavulanate are destroyed while the antibiotic activity is preserved.
Indications:
- Treatment of clinical infections
- Respiratory tract infections caused by Actinobacillus pleuropneumoniae, Pasteurella multocida, Streptococcus suis.
- Gastrointestinal infections caused by Clostridium perfringens., E. coli . and Salmonella typhimurium
Target Species:
Pigs
Dosage & route of administration:
For active ingredient:
Administration in drinking water
10mg of amoxicillin (in the form of trihydrate) and 2.5mg of clavulanic acid (in the form of potassium salt) per kg of body weight twice daily.
Dose for whole product:
2g of product per 100 kg body weight twice daily for 5 days.
Warning & precaution:
- In case of insufficient uptake of feed/ water animals should be treated parenterally.
- Use of the product should be based on susceptibility testing and should take into account official national and regional policies with respect to the use of broad spectrum antibiotics
- Do not use in cases of bacteria sensitive to narrow spectrum penicillins or to amoxicillin as a single substance.
Contra-indications
- Do not use in case of hypersensitivity to penicillin or cephalosporin antibiotics or any of the excipients.
- The product should not be given to rabbits, guinea pigs, hamsters, gerbils or small herbivores.
Side-Effects:
It is known that adverse reactions including mild gastrointestinal signs (diarrhoea and vomiting) and allergic reactions (skin reactions, anaphylaxis) may occur after administration of penicillins.
Withdrawal Periods:
Meat and offal: 1 day.
Storage conditions:
Store below 25 °C.
Keep the container tightly closed in order to protect from moisture.
Store in a dry place.
Packaging:
plastic containers : 100 , 250 , 500 gm and 1 kg.
