Thiage
Moximartiro Pour-on
Oral suspension
For Veterinary Use Only
Composition :
Each 100 ml contains:
Closantel (as closantel sodium dihydrate) 5 gm
Mebendazole 7.5 gm
Properties:
Clomart is a combination of the salicylanilide closantel and the benzimidazole mebendazole. Closantel is highly effective against liver flukes, haematophagous nematodes and larval stages of some arthropods. Mebendazole is highly active against gastro-intestinal nematodes, lungworms and cestodes.
Closantel is an uncoupler of the mitochondrial oxidative phosphorylation resulting in inhibition of the ATP-synthesis. This induces a dramatic change in the energy metabolism which finally leads to the death of the parasite
Mebendazole has a selective anthelmintic action through a specific interaction with the microtubular system destruction of the absorptive cells, leading to an irreversible lytic and death of the worm.
Indications:
For the treatment and control of liver fluke, gastro-intestinal nematodes, lungworms,
cestodes and larval stages of some arthropods.
Trematodes:
Liver flukes:
Fasciola hepatica (adults + 5-8 week immatures)
Fasciola gigantica (adults + 8 week immatures)
Nematodes:
Roundworms:
Haemonchus contortus (adults, immatures, inhibited stages and BZ-resistant strains)
Bunostomum spp. (adult)
Chabertia ovina (adults + immatures)
Gaigeria pachyscelis (adults + immatures)
Oesophagostomum spp. (adults)
Capillaria spp. (adults)
Cooperia spp. (adults)
Nematodirus spp. (adults + immatures)
Ostertagia circumcinta (adults + immatures)
Trichostrongylus axei (adults)
Trichostrongylus colubriformis (adults + immatures)
Trichostrongylus vitrinus (adults)
Trichuris ovis (adults)
Strongyloides papillosus (adults + immature)
Lungworms:
Dictyocaulus filaria (adults + immatures)
Cestodes:
Avitellina spp.
Moniezia spp.
Arthropods:
Oestrus ovis (nasal bot) 1st, 2nd and 3rd instar.
Ticks (Ixodes ricinus) feeding on sheep at the time of treatment are likely to produce
fewer viable eggs
Target Species:
Sheep and lambs.
Dosage& administration:
-Route of administration: orally.
shake well before use
-Invert at least 10 times before use.
Dose for whole product:
1 ml of product /5 kg. b.wt.
– All sheep on infested pasture should be dosed at regular intervals during the fluke season.
– The interval between dosing will depend on the level of pasture contamination in severe; fluke seasons, dosing every 6-8 weeks may be necessary
– The product is active against worm eggs and prevents pasture contamination with fluke eggs for approximately 13 weeks.
– Treatment intervals of 10-12 weeks throughout the fluke season are recommended.
– Because of its long half-life, closantel will protect for several weeks against reinfections with the following species in sheep:
Residual activity Dose (mg/kg) Protection Period
Haemonchus contortus 10 7 weeks
Oesophagostomum columbianum 10 2 weeks
Gaigeria pachyscelis 10 8 weeks
Oestrus ovis 10 8 weeks
The veterinary surgeon should give advice regarding appropriate dosing programmes and stock management to achieve adequate parasite control for both fluke- and roundworm infestations.
Warnings & precautions:
– Care should be taken to avoid the following practices because they increase the risk of development of resistance and could ultimately result in ineffective therapy:
– Too frequent and repeated use of anthelmintics from the same class, over an extended period of time.
– Under dosing which may be due to underestimation of bodyweight, misadministration of the product, or lack of calibration of the dosing device.
– Suspected clinical cases of resistance to anthelmintics should be further investigated using appropriate tests (e.g. Faecal Egg Count Reduction Test). Where the results of the tests strongly suggest resistance to a particular anthelmintic, an anthelmintic belonging to another pharmacological class and having a different mode of action should be used
– The product is to be administered carefully with a drenching gun.
– Care must be taken to avoid causing injury to the mouth or pharynx during dosing.
– Do not exceed the stated dose.
– Wash splashes from eyes and skin immediately.
– Take off immediately any contaminated clothing.
– Wash hands and exposed skin before meals and after work.
Contra-indications
– Do not administer to animals with known hypersensitivity to the active ingredients.
Side-Effects:
- At therapeutic doses, the combination is not toxic and causes no side effects.
- Symptoms of serious closantel overdosage are decreased vision or blindness, anorexia, in-coordination and general weaknes.
Withdrawal Periods:
Sheep (Meat & offal): 65 days
Not authorised for use in ewes producing milk for human consumption including during the dry period. Do not use within 1 year prior to the first lambing in ewes intended to produce milk for human consumption.
Storage conditions:
Store in dry dark and place at temperature not exceeding to 30 o.
Packaging:
20, 25, 30, 50,100, 150, 200, 250, 400, 500 and I000 ml of the product in white HDPE plastic bottle closed by opaque HDPE white screw cap lined with HDPE plastic film with outer label Without Insert
