Doppio colineo
Cilloclav
Egytiam
Composition :
Each 1 ml contains:
Neomycin( as sulfate)………………….. 100.000 IU
Colistin(as sulfate ) ………………………..1.200.000IU
(Eq. To 40 mg/ml)
Properties:
Colistin,(PolymyxinE), polypeptide antibiotics with bactericidal activity, is produced by the anaerobic bacteria Bacillus polymyxa var.colistinus. It interacts with phospholipid and penetrates the membrane structure of bacteria, changing its permeability and decomposition. The antimicrobial action of colistin is limited to Gram-negative bacteria ,including Enterobacter spp, Escherichia.coli, Klebsiella spp, Salmonella spp, Pasteurella spp, Bordetella spp and Shigella spp. Colistin has cross-resistance to other polymyxins.
Neomycin is an aminoglycoside antibiotic with antibacterial activity obtained by fermentation of strains of Streptomyces fradiae, which inhibits the translation process of protein synthesis by interfering with the normal function of the 30S ribosomal subunit. It is mainly acts against Gram-negative aerobic, with very little action and limited on anaerobic Gram- positive. Among the most sensitive to neomycin n Gram negative microorganisms are Escherichia coli, Enterobacter aerogenes, Klebsilla pneumoniae, Proteus vulgaris, Salmonella spp. and Shigella spp. Neomycin has cross-resistance to other aminoglycosides. The association of two antimicrobial, antibacterial has a complementary action with respect to their mechanisms of action.
Indications:
It is used for treatment of :
Bacterial gastrointestinal infections caused by susceptible Escherichia coli in pigs .
Target Species:
Pigs
Dosage & route of administration:
Route of administration :
Orally via drinking water.
For whole product:
0.1 ml of the product / 1kg b.wt. / 5 days.
Warning & precaution:
- For any infectious process is recommended bacteriological confirmation of diagnosis and performing a sensitivity test of the bacteria causing the process.
- Prepare medicated water every 24 hours.
Contra-indications
- Do not administer to animals known to neomycin and / or colistin hypersensitivity.
- Colistin administered with competitive neuromuscular blocking potency of neuromuscular block at risk of respiratory paralysis.
- It is recommended that neomycin is not be administered with other aminoglycosides, neuromuscular blockers, general anesthetics or loop diuretics.
Side-Effects:
- No adverse reactions found for the drug in the target species at the recommended dose.
- Neomycin taken orally for long periods, can induce maldigestion and malabsorption of vitamins, amino acids, calcium, magnesium, lactose and sucrose.
Withdrawal Periods:
Pigs : meat, 2 days.
Storage conditions:
- Keep away from moisture & at temperature not exceeding 30° C.
- Keep out of reach of children.
Packaging:
Plastic containers : 100, 250, 500 ml &1 liter
