Doppio colineo
Fenbendamart 20 % WSP
Premix
For veterinary use only
Composition :
Each 1000 gm contains:
Tiamulin Hydrogen Fumarate 800 gm
Properties:
Tiamulin is a bacteriostatic semi-synthetic antibiotic belonging to the pleuromutilin group of antibiotics and acts at the ribosomal level to inhibit bacterial protein synthesis. Tiamulin has shown a in-vitro activity against a wide range of bacteria such as Brachyspira hyodysenteriae, Brachyspira pilosicoli, Lawsonia intracellularis and Mycoplasma spp.Tiamulin is bacteriostatic at therapeutic concentrations and has been shown to act at the 70S ribosome level and the primary binding site is on the 50S subunit and possibly a secondary site where the 50S and 30S subunits join. It appears to inhibit microbial protein production by producing biochemical inactive initiation complexes, which prevent elongation of the polypeptide chain.
Mechanisms responsible for resistance development in Brachyspira spp to the pleuromutilin class of antibiotics are considered to be based on mutations at the ribosomal target site. Clinically relevant resistance to tiamulin requires combinations of mutations around the tiamulin binding site.
Resistance to tiamulin may be associated with decreased susceptibility to other pleuromutilins.
Indications:
Pigs
For the treatment and prevention of swine dysentery caused by Brachyspira hyodysenteriae.
For the treatment of colitis caused by Brachyspira pilosicoli.
For the treatment of ileitis caused by Lawsonia intracellularis.
For the treatment of enzootic pneumonia caused by Mycoplasma hyopneumoniae.
Chickens
For the treatment and prevention of chronic respiratory disease (CRD) and air sacculitis caused by Mycoplasma gallisepticum and Mycoplasma synoviae.
Turkeys
For the treatment and prevention of infectious sinusitis and air sacculitis caused by Mycoplasma gallisepticum, Mycoplasma meleagridis and Mycoplasma synoviae.
Target Species:
Pigs
Chickens (broiler, replacement pullet, layer/breeder)
Turkeys (poult (grower) and breeder)
Dosage of administration:
Pigs
Treatment of Swine Dysentery : 0.125 – 0.25 kg per one tonne of feed
Prevention of Swine Dysentery : 0.05 kg per one tonne of feed
Treatment of Porcine Proliferative Enteropathy (ileitis) : 0.188 kg per one tonne of feed
Treatment of Enzootic Pneumonia : 0.125 – 0.25 kg per one tonne of feed
Chicken (broiler, replacement pullet, laying and breeding hens)
Treatment and prevention of Chronic Respiratory Disease (CRD): 0.313 -0.625 kg per one tonne of feed
Turkey (young poults, breeding turkeys)
Treatment and prevention of infectious sinusitis and air sacculitis: 0.313 –0.625 kg per one tonne of feed
Warnings:
In case of reduced feed intake, the inclusion levels in feed may need to be increased to achieve target dosage. Acute cases and severely diseased animals with reduced feed intake should be treated with a product of suitable formulation such as an injectable or water solution.
Contra-indications
Animals should not receive products containing ionophores (monensin, narasin or salinomycin) during or for at least seven days before or after treatment with tiamulin. Severe growth depression or death may result.
Side-effects:
On rare occasions erythema or mild oedema of the skin may occur in pigs following the use of tiamulin.
Withdrawal periods:
Pigs
Prevention (at 2.0 mg/kg bwt): 1 day
Treatment (at 5-10 mg/kg bwt): 6 days
Chickens
Meat and offal: 1 day
Eggs: 0 days
Turkeys
Meat and Offal: 4 days
Storage:
Stored at temperature not exceeding 30 c in dry place and used immediately after opening
After mixing :used for 3 months after mixing with feed (a crushed corn for layers) when stored at temperature not exceeding 30 C
Packaging:
Colorless plastic ( LDPE) bag containing 20,25,50,100,150,200, 250, 300,500,1000 gm of the product in white ( HDPE) plastic jars with an outer label with white ( HDPE) plastic cap without insert
