Fenbendamart
Glucamar
Oral Suspension
For Veterinary Use Only
Composition :
Each liter contains
Oxfendazole 90.6 gm
Properties:
Oxfendazole belongs to a class of compounds, the benzimidazoles.
The Benzimidazoles possess anti-mitotic properties, and this action is related to their capacity to bind to tubulin leading to inhibition of formation of microtubules. This, in turn, leads to disruption of cell division. Eventually cell lysis and disintegration occur.
Oxfendazole may concentrate preferentially in intestinal cells of parasites to exert its toxic effects initially and principally at this site. Similar effects do not occur in host cells, possibly because of differential binding characteristics. The disruption of parasite metabolic processes, and the effects of oxfendazole on enzymes of helminth parasites, involves inhibition of glucose and sodium uptake, reduced muscle glycogen content, uncoupling of oxidative phosphorylation and inhibition of malate dehydrogenase and fumarate reductase.
Indications:
For the treatment of cattle and sheep infested with the following species:
- -GASTROINTESTINAL ROUNDWORMS caused by Ostertagia spp, Haemonchus spp, Nematodirus spp, Trichostrongylus spp, Cooperia spp, Oesophagostomum spp, Chabertia spp, Capillaria spp , Trichuris spp.
- LUNGWORMS caused by Dictyocaulus spp.
- TAPEWORMS caused by Moniezia spp.
Target Species:
Cattle and Sheep
Dose For active ingredient:
Cattle: 4.5 mg oxfendazole per kg bodyweight.
Sheep: 5.0 mg oxfendazole per kg bodyweight.
Dose for whole product:
Cattle: Above 300 kg give a further 2.5 ml for each additional 50 kg bodyweight.
| Bodyweight | Dose |
| 100 kg | 5 ml |
| 150 kg | 7.5 ml |
| 200 kg | 10 ml |
| 250 kg | 12.5 ml |
| 300 kg | 15 ml |
Sheep: Above 80 kg give a further 0.5 ml for each additional 9 kg bodyweight.
| Bodyweight | Dose |
| Up to 17 kg | 1.0 ml |
| 18 – 25 kg | 1.5 ml |
| 26 – 35 kg | 2.0 ml |
| 36 – 44 kg | 2.5 ml |
| 45 – 60 kg | 3.5 ml |
| 61 – 80 kg | 4.5 ml |
For oral administration only. Give the recommended dose by mouth using standard dosing equipment. Dosing may be repeated at required intervals.
Shake the container before use
Do not mix with other products
Warnings & precautions:
Care should be taken to avoid the following practices because they increase the risk of development of resistance and could ultimately result in ineffective therapy:
– Too frequent and repeated use of anthelmintics from the same class, over an extended period of time.
– Under dosing, which may be due to underestimation of body weight, misadministration of the product, or lack of calibration of the dosing device (if any)
Suspected clinical cases of resistance to anthelmintics should be further investigated using appropriate tests (e.g. Faecal Egg Count Reduction Test). Where the results of the test (s) strongly suggest resistance to a particular anthelmintic, an anthelmintic belonging to another pharmacological class and having a different mode of action should be used.
Resistance to benzimidazoles has been reported in Teladorsagia, Haemonchus, Cooperia and Trichostongylus species in small ruminants. Therefore the use of this product should be based on local (regional, farm) epidemiological information about susceptability of nematode and recommendations on how to limit further selection for resistance to anthelmintics.
Contra-indications
Oxfendazole should not be administered simultaneously with bromsalan flukicides (oxyclozanide). This combination has produced some abortions in cattle and deaths in sheep
Side-Effects:
Hypersensitivity reactions secondary to antigen release by dying parasites are theoretically possible, particularly at high dosages.
Withdrawal Periods:
Cattle ( meet ): 9 days
Sheep ( meet ) : 21 days
Not for use in cattle or sheep producing milk for human consumption.
Storage conditions:
Store in dry place at room temperature and protected from direct sunlight.
Packaging:
100, 250, 500 and 1000 ml. Plastic bottles.
