Glucamar
Fendazomart
Hatchdor
Solution For Injection
Composition :
Each 100 ml contains
Nitroxynil ( As N-ethylglucamine salt) 34 gm
Properties:
Nitroxynil act as Flukicide and nematicide anthelmintic, endoparasiticide , the main pharmacological action of nitroxynil is fasciolicidal. The lethal action against Fasciola hepatica has been demonstrated in vitro and in vivo in laboratory animals, and in sheep and cattle. The mechanism of action is thought to be due to uncoupling of oxidative phosphorylation.
Few other pharmacodynamic effects have been observed in therapeutic doses.
Hyperpnoea and increased rectal temperature are seen at high doses, and near toxic doses cause an increase in blood pressure.
The pharmacokinetics of nitroxynil in sheep and cattle are very similar. .
Nitroxynil is active against triclabendazole-resistant Fasciola hepatica.
Indications:
Glucamar is indicated for the treatment of fascioliasis ( infestation of mature and immature Fasciola hepatica) in cattle and sheep. It is also effective, at the recommended dose rate, against adult and larval infestations of Haemonchus contortus in cattle and sheep and Haemonchus placei, Oesphagostomum radiatum and Bunostomum phlebotomum in cattle.
Target Species:
Sheep and cattle.
Dose for active ingredient:
Administer by subcutaneous injection.
Sheep and cattle : 10 mg Nitroxynil per Kg bodyweight
Dose for whole product:
Sheep : 0.5 ml per 14-20 kg body weight
Cattle : 1.5 ml per 50 kg body weight
Warnings & precautions:
Do not retreat at intervals less than 60 days (cattle) or 49 days (sheep).
Care should be taken to avoid the following practices because they increase the risk of development of resistance and could ultimately result in ineffective therapy:
• Too frequent and repeated use of anthelmintics from the same class, over an extended period of time.
• Underdosing, which may be due to underestimation of body weight, misadministration of the product, or lack of calibration of the dosing device (if any).
Contra-indications
- Do not use in animals with known hypersensitivity to the active ingredient.
- Do not use in dogs as fatalities have been reported.
- Do not exceed stated dose
Side-Effects:
- Small swellings are occasionally observed at the injection site in cattle.
- These can be avoided by injecting the dose in two separate sites and massaging well to disperse the solution.
Withdrawal Periods:
- Cattle may be slaughtered for human consumption only after 60 days from the last treatment.
- Sheep may be slaughtered for human consumption only after 49 days from the last treatment
Storage condations:
Store in dry dark and place at temperature not exceeding to 30 o.
Packaging:
Vial of 50,100 and 250 ml.
