Glucamar
Martilmico 30 % inj
Solution For Injection
For Veterinary Use Only
Composition :
Each ml contains
Doramectin 10 mg
Clorsulon 100 mg
Properties:
The primary mode of action of avermectins like doramectin is to affect chloride ion channel activity in the nervous system of nematodes and arthropods. Doramectin binds to receptors that increase membrane permeability to chloride ions. This inhibits the electrical activity of nerve cells in nematodes and muscle cells in arthropods and causes paralysis and death of the parasites. Avermectins also enhance the release of gamma amino butyric acid (GABA) at presynaptic neurons. GABA acts as an inhibitory neurotransmitter and blocks the post-synaptic stimulation of the adjacent neuron in nematodes or the muscle fiber in arthropods. Avermectins are generally not toxic to mammals as they do not have glutamate-gated chloride channels and these compounds do not readily cross the blood-brain barrier where mammalian GABA receptors occur.
Clorsulon inhibits the glycolytic enzymes 3-phosphoglycerate kinase and phosphoglyceromutase, thereby blocking the Emden-Myerhof glycolytic pathway. The fluke is deprived of its main metabolic energy source and dies
Indications:
- Gastrointestinal roundworms (adults and immature stage of ): Ostertagia ostertagi (including inhibited larvae) – small brown stomach worm , Ostertagia lyratai, Trichostrongylus sp.- stomach hair worm , T. colubriformis- Black Scour worm , T. longispicularis ( adults only ) , Cooperia oncophora- small intestinal worm, C. punctata, C. surnabada ( mcmasteri),N.spathiger ( adults only ), S. papillosus ( adults only ), Bunostomum phlebotomum ( adults only ) – hook Worm , Oesophagostomum radiatum- Nodule worm , Trichuris spp. ( adults only )
- Lungworms: Dictyocaulus viviparous (adults and immature )
- Liver fluke: Fasciola hepatica(adults)
Target Species:
Cattle.
Dose for active ingredient:
By Subcutaneous injection ( just under the skin ) on the side of the neck, preferably high up behind the ear
Cattle : 0.2 mg Doramectin, 2 mg Clorsulon per kg body weight
Dose for whole product:
Cattle : 1 ml per 50 kg body weight
Warnings & precautions:
Intramuscular injections may have a higher incidence of injection site blemishes at slaughter than do subcutaneous injections.
Contra-indications
Studies performed in breeding animals (bulls, and cows in early and late pregnancy), at a dose of 3X recommended had no effect on breeding performance
Side-Effects:
Soft-tissue swelling at the injection site can occur . these reactions usually disappear without treatment .
Withdrawal Periods:
Meat : 63 days
Milk : 42 days
Storage conditions:
Store in dry dark and place at temperature not exceeding to 30 o.
Packaging:
Vial of 50,100 and 250 ml.
