Fenbendamart 20 % WSP
Lincogerm
Oral Suspension
For Vet. Use
Composition :
Each 1 ml contains:
Ketoprofen 300 mg
Properties:
Ketoprofen is a non-steroidal anti-inflammatory drug belonging to the arylpropionic acid group. Ketoprofen inhibits the biosynthesis of prostaglandins (PGE2 & PGF2α) without affecting the ratio of PEG2/PGF2α & thromboxanes. This mechanism of action results in its anti-inflammatory, antipyretic & analgesic activity. These properties are also attributed to its inhibiting effect on bradykinin & superoxide anions together with its stabilizing action on lysosomal membranes. The anti inflammatory effect is enhanced by the conversion of the ( R )- enantiomer to (S)- enantiomer. It is known that the (S)-enantiomer supports the anti-inflammatory effect of ketoprofen. Following oral administration, ketoprofen is readily absorbed & binds strongly to plasma proteins. Ketoprofen is metabolized in the liver & converted into a carbonil-reduced derivation, the RP69400 metabolite. It is excretedprimarily through the kidneys &, to a lesser extent, in the faeces.
Indications:
Treatment for the reduction of pyrexia and dyspnoea associated with respiratory disease in combination with appropriate anti-infective therapy.
Target Species:
Fattening Calves – Pigs
Dosage & Route of administration:
Taken orally via drinking water
For active ingredients:
- Fattening calves: 3 mg ketoprofen / kg b.wt.
- Pigs: 1.5 – 3 mg ketoprofen / kg b.wt.
For whole product:
- Fattening calves: 1 ml of product / 100 kg b.wt. in drinking water
- Pigs: 0.5 – 1 ml of product / 100 kg b.wt. in drinking water
Treatment should be given for one day. It can be continued for another 1-2 days after a risk/benefit assessment by the responsible veterinarian.
Warnings and Precautions:
- Water intake of treated animals should be monitored to ensure adequate intake.
Individual animal medication, preferably by injection, will be required if daily
water intake is insufficient. - As ketoprofen may provoke gastrointestinal ulcerations, the use is not recommended in cases of PMWS (post-weaning multisystemic wasting syndrome) because ulcers are already frequently associated with this pathology.
- To reduce the risk of adverse reaction do not exceed the recommended dose or duration of treatment.
- When administrating to very young animals it is necessary to adjust the dose accurately as well as to perform a close clinical follow up.
Contra-indications
- Do not use in pregnant sows.
- Do not administer to suckling calves.
- Do not administer to fasting animals or animals with limited access to feed.
- Do not use in animals where there is the possibility of gastrointestinal alterations, ulceration or bleeding in order not to aggravate their situation.
- Do not use in dehydrated or hypovolemic or hypotensive animal due to the potential nrisk of increased renal toxicity.
- Do not administer to swine fattened at extensive or semi-extensive production farms.
- Do not use in animals suffering from cardiac, hepatic, or renal disease.
- Do not use where there is evidence of blood dyscrasia.
- Do not use in animals with a history of hypersensitivity to ketoprofen, aspirin or any of the excipients.
Side-effects:
- Overdose with NSAIDS can lead to gastro-intestinal ulceration, loss of proteins, hepatic & renal impairment.
- Early signs of toxicity include loss of appetite & pasty faeces or diarrhoea.
Withdrawal time:
Meat & offal : 24 hours
Storage:
Store at temperature not more than 30°C.
Packaging:
Plastic containers : 100, 250, 500 ml &1 liter
