Kuranium
Dectarium
Zolamartiros
Composition :
Each 1L contains :
Abamectin 1 gm
Selenium (as Sodium Selenate) 0.5 gm
Triclabendazole 50 gm
Properties:
Kuranium is an oral anthelmintic containing Abamectin, Triclabendazole and Selenium.
Abamectin have a broad spectrum of activity and are active against mature and immature nematode and arthropod parasites of mammals, fish and other vertebrates. It owes its action to selective and high affinity binding of the molecules to glutamate-gated chloride ion channels that occur in invertebrate nerve and muscle cells. This leads to an increased permeability of the cell membrane to chloride ions with hyperpolarisation of the nerve or muscle cell resulting in paralysis and death of the parasite.
Triclabendazole differs from other benzimidazoles in that it is a narrow spectrum anthelmintic. The drug accumulates significantly in both immature and adult stages of Fasciola hepatica and stimulates the major routes of the parasite’s energy generating system, as demonstrated by glucose derived acetate and propionate formation. However, under these conditions the parasite’s motility decreased, indicating that the drug is not associated with inhibition of the energy generating pathways. Triclabendazole inhibits colchicine binding to microtubular proteins suggesting interference of the drug with microtubular structure and function. The drug strongly inhibits the release of proteolytic enzymes in immature and adult parasites, a process dependant on microtubular functions
Selenium is as a component of the enzyme glutathione peroxidase (GSH-PX). The exact role of GSH-PX in mammalian cells is not fully understood but it is thought to act by protecting cells from oxidizing agents which are capable of irreversibly denaturing essential cellular proteins which leads to degeneration and necrosis, resulting in muscular weakness and white muscle disease commonly associated with selenium deficiency. It is believed that a deficiency in selenium can cause a decrease in the humoral response of animals to vaccination and increase the susceptibility of animals to disease. The symptoms are most pronounced in young fast growing animals.
Indications:
For the treatment of sensitive strain of the following adult and immature parasites of sheep:
Adult and immature gastrointestinal roundworms:
(Haemonchus contortus) Barbers pole worm
(Trichostrongylus axei) Stomach hair worm
(Ostertagia [Teladorsagia] spp) Small brown stomach worm
(Trichostrongylus spp) Black scour worm
(Cooperia spp) Small intestinal worm
(Nematodirus spp) Thin necked intestinal worm
(Oesophagostomum columbianum) Nodule worm
(Oesophagostomum venulosum) Large bowel worm (Chabertia ovina) Large mouthed bowel worm (Trichuris ovis) Whipworm
(Strongyloides papillosus) Intestinal threadworm
Lungworm:
(Dictyocaulus filaria) Large lungworm
Also treats and controls:
(Oestrus ovis) Nasal bot
(Psorergates ovis) Itch mite
Liver Fluke:
For the treatment of susceptible Early Immature, Immature and Mature liver fluke (Fasciola hepatica) in sheep.
Reduces worm egg hatching. For this to be of benefit, sheep should not be placed on clean pasture until 6 hours after drenching.
Target Species:
Sheep
Dosage & route of administration:
Route of administration: orally (shake well before use)
For whole product:
1ml of product/ 5kg.b.wt
The treatment should be repeated after 21 days.
Warnings :
-Do not use on female sheep which are producing or may in the future produce milk or milk products for human consumption.
-This product should not be used when selenium intake from pasture is high. Selenium can have toxic effects, particularly in sheep with liver damage that graze in areas where plants that contain pyrrolizidine alkaloids are prevalent.
-Dose the mob to the heaviest animal by live weight, in each group (ewes, lambs, rams).
-Do not under dose. Where there is a large variation in size within the group, dose rate should be based on the label direction for each weight range.
-Drafting into two or more lines may be appropriate, to avoid excessive overdosing.
Side effect:
Poisonous if absorbed by skin contact or swallowed.
Will irritate the eyes and skin
Withdrawal Periods:
Meat: do not use less than 21 days before slaughter for human consumption.
Milk: do not use in ewes which are producing milk or milk products for human consumption.
Do not use less than 21 days before lambing in ewes where milk and milk products from treated animals may be used for human consumption.
When is given accidentally to ewes within this period or should any ewes lamb earlier than 21 days after treatment, milk will contain residues. This milk must not be used for human consumption, or supplied for processing for at least 21 days following treatment. Lambs fed this milk should not be slaughtered for human consumption within 7 days.
Contra-indications:
– Do not use in cases of known hypersensitivity to the active substance or any of the excipients.
– This product is contraindicated for use in lambs under six (6) weeks of age or less than 10kg bodyweight.
– Do not drench lambs in marking or mulesing cradles due to increased risk of aspiration into the lungs.
In areas where Black disease occurs, vaccination is recommended.
Storage:
Store at a temperature not exceeding 30°C
Packaging:
Opaque white (HDPE) plastic bottle contains 20, 25, 30, 50, 100, 150,200, 250,300,400,500, 750, 1000 ml oral Solution with (HDPE) plastic cap safety by Aluminum sealed with an outer label without Insert
