Martilevrokan
Kazodexdal
Pour-on solution
For veterinary use only
Composition :
Each 1ml contains:
Each ml of solution contains:
Ivermectin 5 mg
Properties:
Ivermectin is a mixture of two compounds belonging to the Ivermectin family, which are a macrocyclic lactone group of endectocides. Ivermectin is a microbial metabolite of the soil organism Streptomyces avermilitis. It is generally accepted that ivermectin exerts its action in two main ways, interference with neurotransmission and opening chloride ion channels. The effect of ivermectin on the parasitic CNS is considered to operate through glutamate-mediated chloride channels. Compounds of this class may also interact with other ligand-gated chloride channels, such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA). The opening of pre-synaptic chloride ion channels results in an efflux of chloride ions and depolarisation of the nerve terminal. These effects interfere with normal neurotransmission between nerves and muscles, resulting in parasite paralysis and eventual death.
Indications:
For the treatment of infections with the following parasites:
In cattle:
- Gastro-intestinal worms :
Haemonchus placei (adult and fourth stage larvae)
Ostertagia ostertagi (adult and fourth stage larvae, including inhibited larvae)
Trichostrongylus axei (adult and fourth stage larvae)
Trichostrongylus colubriformis (adult and fourth stage larvae)
Cooperia punctata (adult only)
Cooperia oncophora (adult only)
Strongyloides papillosus (adult only)
Oesophagostomum radiatum, (adult and fourth stage larvae)
- Lungworm (adult and fourth stage larvae) – Dictyocaulus viviparus.
- Warbles (parasitic stages) – Hypoderma bovis, Hypoderma lineatum.
- Product has persistent activity against infections acquired with Trichostrongylus axei and Cooperia spp. up to 14 days after treatment, but only in the case of group treatment; Ostertagia ostertagi and Oesophagostomum radiatum up to 21 days after treatment; Dictyocaulus viviparus up to 28 days after treatment. It also has persistent activity against horn flies (Haematobia irritans) for up to 28 days after treatment; partial efficacy against Haematobia irritans may last for up to 35 days post application.
Target Species:
Cattle.
Dosage & route of administration:
Route of administration: For single topical application.
The formulation should be applied along the mid-line of the back in a narrow strip between the withers and tail head. The 250 ml and 1.0 litre packs must be used with appropriate dosing equipment.
For whole product:
– 1ml of solution per 10 kg body weight.
Warnings :
- Do not treat cattle when their hide is wet.
- Do not treat cattle if rain is expected, as rain within 2 hours of treatment may reduce efficacy.
- Do not apply to areas of skin which have mange scabs or other lesions, or to areas contaminated with mud or manure.
- To avoid secondary reactions due to the death of Hypoderma larvae in the oesophagus or in the spine, it is recommended to administer the product at the end of warble fly activity and before the larvae reach their resting sites.
Side effect:
- None known.
Withdrawal Periods:
- Meat and offal: 31 days.
- Milk: Not permitted for use in lactating cattle producing milk for human consumption.
Do not use in non-lactating dairy cows, including pregnant dairy heifers, within 60 days of calving.
Contra-indications:
- Do not use in cases of known hypersensitivity to the active ingredient.
- Do not use in lactating dairy cows producing milk for human consumption.
- Do not use in non-lactating dairy cows, including pregnant dairy heifers, within 60 days of calving.
- The product has been formulated for topical application specifically for cattle. It should not be administered to other species as severe adverse reactions, including fatalities in dogs, may occur.
Storage:
Store at a temperature not exceeding 30°C, Used immediately after opening
Packaging:
50, 100, 150, 200, 250, 500, 750 and 1000 ml of pour -on solution in opaque white (HDPE) plastic bottle closed by white (HDPE) plastic cap with aluminum seal with an outer label without insert
