Martifenac
Composition :
Each 1 ml contains:
Diclofenac Sodium 53.7 mg (Eq. to 50 mg Diclofenac Base )
Properties:
Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory activity, analgesic and antipyretic.
It acts at the level of arachidonic acid metabolism by inhibiting the enzyme cyclooxygenase, responsible for the synthesis of prostaglandins, prostacyclin and thromboxanes.
Indications:
Cattle, Pigs and Horses not intended for human consumption:
Reduction of pyrexia and inflammation, in pathologies of the respiratory system (ex: bronchopneumonia), of the genitourinary system (eg: metritis) and the mammary gland (eg: mamitis) and musculoskeletal conditions (eg, acute and chronic lameness, arthritis, desmitis, tendonitis, myositis).
Target Species:
Cattle, Pigs and Horses not intended for human consumption.
Dosage and administration:
Route: By I/M route only:
Dose for active ingredient:
Horses: 2.3 mg of diclofenac / kg bodyweight / day)
once daily for 3 – 5 days.
Dose for whole product:
Route:
Cattle and Pigs: Administer intramuscularly.
Horse: The intramuscular route is recommended. In case of need, it is possible to intravenous administration.
Cattle: 4.6 ml / 100 kg B.W. for 1 – 3 days.
In the case of acute lameness, 2.3 ml / 100 kg B.W. for 3 days.
Pigs: 1.15 ml / 25 kg B.W. for 3 days.
Horse: 4.6 ml / 100 kg B.W. for 3-5 days.
Respect a maximum volume per injection point of:
Cattle: 12 ml
Pigs: 3 ml
Provide sufficient separation between the injection points when several places of administration.
Warnings:
– Do not administer to horse whose meat or milk is destined for human consumption.
– Do not exceed the dosage or the duration of the prescribed treatment.
– Avoid use in dehydrated, hypovolemic or hypotensive animals, since there may be a potential risk of increased renal toxicity.
– Do not administer to animals susceptible to enter the food chain of wild fauna.
Its use is not recommended during pregnancy.
Contra-indications:
– Do not use in case of known hypersensitivity to the active substance or any of the excipients
– Do not use in animals suffering from gastrointestinal disorders, particularly in the presence of ulcerative lesions, since diclofenac can aggravate the symptoms and cause hemorrhages.
– Do not use in animals with liver, cardiac or renal dysfunction or in animals with disorders hemorrhagic.
– It is recommended not to administer simultaneously with glucocorticoids, other non-steroidal anti-inflammatories, or anticoagulants.
Aminoglycosides, glucocorticoids, NSAIDs and other substances with a high degree of protein binding Plasma can compete to join these and cause toxic effects. The simultaneous administration of potentially neurotoxic active substances.
Side-Effects:
– Due to the mechanism of action of NSAIDs (inhibition of prostaglandin synthesis) irritation or gastrointestinal ulceration, renal failure and alterations may occur liver, even after proper use.
– In cattle, intramuscular injection may cause moderate pain and transient swelling at the injection point.
– In pigs, these reactions were not observed.
– In the horse, anorexia and hemorrhages may appear even at the recommended posology.
– Transient swelling may occur at the point of intramuscular administration injection.
– Rarely, allergic reactions may occur.
Withdrawal Periods:
Cattle: Meat: 15 days
Milk: 144 hours (6 days)
Pigs: Meat: 12 days
Horse: Not applicable. Its use is not authorized in horse whose meat or milk is destined for human consumption.
Storage:
Store at temperature not exceeding 30°C and used immediately after opening.
Packaging:
Carton Box containing Colorless glass ( Type II ) vials containing 100 ml solution closed with bromobutyl rubber stopper and non-reusable aluminum closures with an outer label and insert leaflet.
