Composition:

Each 1ml contains:
Rafoxanide 30 mg
Levamisole Hydrochloride 30 mg

Properties:

Martilevrokan contains both Rafoxanide, a fasciolicide, and Levamisole HCl an anthelmintic in fixed combination. Rafoxanide is a salicylanide derivative and has been used as a fasciolicide for several years. It acts by uncoupling oxidative phosphorylation in the parasitic cells, gradually depriving them of energy. Because it is highly protein bound it is only activated when released from the plasma proteins by the action of blood sucking organisms and therefore is selective for fasciola and blood sucking organisms.
It is absorbed slowly, binds to plasma proteins and is slowly eliminated from the body. Levamisole is the l-isomer of the anthelmintic tetramisole. It acts as a cholinergic agonist causing depolarising ganglionic blockade of the parasite’s neuromuscular junction. It is quickly and extensively absorbed form the gastrointestinal tract and is also quickly eliminated.

Indications:

For the treatment of:
Roundworm, lungworm and fluke infections in cattle and sheep. It is highly effective against
mature and developing immature stages of levamisole-susceptible major stomach and bowel worm species including: Trichostrongylus spp, Cooperia spp, Ostertagia spp (except Ostertagia larvae in cattle), Haemonchus spp, Nematodirus spp, Bunostomum spp, Oesophagostomum spp, Chabertia spp, and lungworms (Dictyocaulus spp.).
It also effective against mature liverfluke in cattle and sheep.

Target Species:

Cattle and Sheep.

Dosage & Route of administration:

– Oral administration only.
– Shake well before use.
For whole product:
12.5 ml of of product /50 kg.b.wt. Administered orally once without exceeding the total dose per animal.
– Repeat treatment after 21days.

Warnings:

– Care should be taken to avoid the following practices because they increase the risk of development of resistance and could ultimately result in ineffective therapy:
*Too frequent and repeated use of anthelmintics from the same class, over an extended period of time.
*Underdosing which may be due to underestimation of bodyweight, misadministration of the product, or lack of calibration of the dosing device.
*Suspected clinical cases of resistance to anthelmintics should be further investigated using appropriate tests (e.g. Faecal Egg Count Reduction Test). Where the results of the tests strongly suggest resistance to a particular anthelmintic, an anthelmintic belonging to another pharmacological class and having a different mode of action should be used.
-Where a dosing gun is used to administer the product, care should be taken to avoid the occurrence of dosing gun pharyngitis.
-Shake the container before use.
-Avoid the introduction of contamination during use.
-Not to be diluted or mix with other products.
-The product is safe for use during pregnancy

Contra-indications:

– Do not use in animals with known hypersensitivity to the active ingredients.
– Do not use in animals less than 6 months of age.
– Animals should not be treated simultaneously with products containing organophosphorous compounds or diethyl carbamazine citrate
– Any such treatment should not take place within 14 days before or after the use of the product.

Adverse effects :

– Occasionally, at the recommended dose, cattle may show signs of lip-licking and slight muscle tremors.

Withdrawal Periods:

– Animals intended for human consumption must not be slaughtered during treatment.
– Cattle and sheep may be slaughtered for human consumption only after 60 days from the last treatment.
– Cattle: Not authorised for use in cattle producing milk for human consumption, including pregnant cattle intended to produce milk for human consumption.
Sheep: Not authorised for use in ewes producing milk for human consumption including during the dry period. Do not use within 1 year prior to the first lambing in ewes intended to produce milk for human

Storage Conditions:

Store at a temperature not exceeding 30°C

Packaging:

100, 250, 500 and 1000 ml of the product in white HDPE plastic bottle closed by opaque HDPE white screw cap lined with HDPE plastic film with outer label without Insert