Martigent 50
Martimulin
Oral Solution
For veterinary use only
Composition :
Each 1 ml contains:
Tilmicosin phosphate (Equivalent to Tilmicosin 250 mg ) 278.2 mg
Properties:
Tilmicosin is a semi-synthetic antibiotic of the macrolide group, and is believed to affect protein synthesis. It has bacteriostatic action but at high concentrations it may be bactericidal. This antibacterial activity is predominantly against Gram-positive microorganism with activity against certain gram-negative ones and Mycoplasma of a bovine, porcine, ovine and avian origin. In particular, its activity has been demonstrated against the following microorganism. Mycoplasma hyopneumoniae, Pasteurella multocida , Actinobacillus pleuropneumoniae , Mycoplasma gallisepticum , Mycoplasma synoviae , Mannheimia haemolytica, Pasteurella multocida, Mycoplasma bovis and M. dispar
Scientific evidence suggests that macrolides act synergistically with the host immune system. Macrolides appear to enhance phagocyte killing of bacteria. Tilmicosin has been shown to inhibit in vitro the replication of the Porcine Reproductive and Respiratory Syndrome virus in alveolar macrophages in a dose dependent fashion.
Indications:
Pigs:
treatment and prevention of respiratory disease in pig herds, associated with Mycoplasma hyopneumoniae, Pasteurella multocida, Actinobacillus pleuropneumoniae and other organisms susceptible to tilmicosin.
Chickens:
treatment and prevention of respiratory disease in chicken flocks, associated with Mycoplasma gallisepticum and M. synoviae.
Turkeys:
treatment and prevention of respiratory disease in turkey locks, associated with Mycoplasma gallisepticum and M. synoviae.
Calves:
treatment and prevention of bovine respiratory disease, associated with Mannheimia haemolytica, Pasteurella multocida, Mycoplasma bovis, M. dispar and other organisms susceptible to tilmicosin.
Target Species:
Chickens ,Turkeys, Pigs and Calves (non ruminant)
Dose for active ingredient:
Pigs:
15 20 mg tilmicosin per kg bodyweight daily for 5 days
Chickens :
15-20 mg/kg bodyweight daily in chickens
Turkeys
10-27 mg/kg bodyweight in turkeys for 3 days
Calves:
12.5 mg/kg bodyweight and given twice daily for 3-5 consecutive days
Dose for whole product:
Pigs:
0.06-0.08 ml of product / kg bodyweight or 6-8 ml/ 100 kg
Chickens
30 ml product per 100 litres.
Turkeys
30 ml product per 100 litres.
Calves:
1 ml of product every 20 kg bodyweight
Warnings:
Important: Must be diluted before administration to animals
Pigs, chickens and turkeys: Water consumption should be monitored in order to guarantee adequate dosing. In case water consumption does not match quantities for which recommended concentrations were calculated, the concentration of product has to be adapted in a way that the recommend dosage will be taken up by the animals or different medication should be considered.
Contra-indications
- Do not allow horses and other equines access to drinking water containing tilmicosin.
- Do not use in case of hypersensitivity to tilmicosin or to any of the excipients.
- Do not administer to ruminating animals with active rumen function.
Side-effects:
In very rare cases, a decrease in water intake has been observed.
Withdrawal periods:
Meat and offal of:
Pigs : 14 days
Chickens : 12 days
Turkeys : 19 days
Calves : 42 days
Storage :
Store at a temperature not exceeding 30°C and used immediately after opening
Packaging:
White (HDPE) plastic bottle contains 20,25,50,100,150,200, 250, 300,500,1000 ml oral solution. lined with red (HDPE) plastic film closed by white plastic (HDPE) cap with white (LDPE) plastic foam .With outer label without Insert
