Powder for use in drinking water

For Veterinary Use Only

Composition :

Each 1kg contains:
Amprolium (as Hydrochloride) 250 gm.
Ethopabate 16 gm.

Properties:

Martirolium Plus is an amprolium-ethopabate combination used for treatment of coccidiosis in poultry, containing amprolium and ethopabate that provides a synergistic effect, which is highly effective in the control of major coccidiosis causing Eimeria species of poultry ex : (E.tenella , E.maxima , E.acervulina , E.brunetti , E.necatrix). Amprolium is an anticoccidial agent that acts as competitive inhibitor of thiamine in the parasite metabolism, and interferes with the metabolism of glucides necessaries for coccidian multiplication and survival. It exhibits high activity against E.tenella and E.acervulina. Ethopabate is a folic acid antagonist. It is structural antagonists of folic acid or of para-aminobenzoic acid (PABA), which is a precursor of folic acid (The host does not synthesize folic acid and has no requirement for PABA). Ethopabate has anticoccidial activity specially against E.maxima and E.brunetti ; and the synergistic combination of amprolium hydrochloride and ethopabate is effective against E.necatrix.

Indications:

For the treatment of coccidiosis in broiler chickens caused by E.tenella , E.maxima , E.acervulina , E.brunetti and E.necatrix.

Target Species:

Broiler chickens

Dose for whole product:

• Route: Orally via drinking water.
• For active ingredient:20 mg amprolium+ 1.28 mg ethopabate / kg. b.wt in drinking water daily for 5-7days.
• For whole product: 0.8 gm of product / 1Liter in drinking water daily for 5-7 day.

Warnings:

• As with any antiparasiticide, frequent and repeated use of antiprotozoals from the same class may lead to the development of resistance.
Special precautions for use:
Special precautions for use in animals:
• The product is not intended for preventive use.
• his product should be reserved for use in case of coccidiosis outbreaks due to non-availability of vaccine, in case of lack of efficacy of vaccine and in vaccinated flocks if a severe coccidial challenge is diagnosed before immunity has fully developed.
• Medicated drinking water should be replaced every 24 hours.
Special precautions to be taken by the person administering the veterinary medicinal product to animals:
• This product is acidic and may cause irritation to, or corrosion of, the skin, eyes,throat and airways.
• Avoid all physical contact with the product, including any vapors.
• Do not eat, drink or smoke whilst handling this product.
• Wear impervious gloves and protective glasses when handtling the product.
• In the case of contact with skin or eyes, wash the affected area with clean running water immediately and remove any contaminated clothes. If irritation persists, seek medical advice and show the label to the physician.
• In case of accidental ingestion, rinse the mouth with fresh water, seek medical advice immediately and show the label to the physician
• Those with known hypersensitivity to amprolium or to any of the excipients should avoid contact with the product.
• Wash hands and exposed skin after use.
Use during pregnancy, lactation or lay:
• Studies in laboratory animals have not produced any evidence of teratogenic effects.
• The safety of amprolium has not been investigated in laying birds.
• Use only according to the risk/benefit assessment by the responsible veterinarian.

Contra-indications

• Do not use in birds producing eggs for human consumption.
• Do not administer to debilitated birds
• Do not use in case of hypersensitivity to the active substance or to any of the excipients.
• Treatment is usually no longer than 14 day.

Drug-drug interaction:

• Amprolium is a thiamine analogue. Therefore, the efficacy of amprolium may be reduced during a simultaneous administration of products containing vitamin B-complex.

Side effects:

• None known.

Poisoning:

• Prolonged uses can produce high thiamine deficiency.
• Occasionally may cause GI or neurologic effects

Withdrawal periods:

• Meat :3days
• Do not use in birds producing eggs for human consumption.

Storage condition:

• Stored at temperature not exceed 30°C.

Packaging:

• Plastic containers: 100, 250 ,500 gm & 1kg.