Erythrorous 18.5%
MartiStreptin
W.S.P.
For veterinary use only
Composition :
Each 100 gm contains:
Amprolium (as Hydrochloride) 25 gm
Ethopabate 0.8 gm
Properties:
Martirolium Premix is an amprolium-ethopabate combination used for treatment of coccidiosis in chickens. It provides a synergistic effect , which is highly effective in the control of major coccidiosis causing E. spp in chickens ex (E.tenella , E.maxima , E.acervulina , E.brunetti , E.necatrix, E. mitis, E. praecox, E. hagani). Amprolium is an anticoccidial agent that acts as competitive inhibitor of thiamine in the parasite metabolism, and interferes with the metabolism of glucides necessaries for coccidian multiplication and survival. It exhibits high activity against E.tenella and E.acervulina. Ethopabate is a folic acid antagonists and It is a structural antagonists of para-aminobenzoic acid (PABA), which is a precursor of folic acid (The host does not synthesize folic acid and has no requirement for PABA) Ethopabate has anticoccidial activity specially against E.maxima and E.brunetti ; and the synergistic combination of amprolium hydrochloride and ethopabate is effective against E.necatrix.
Indications:
For the treatment of coccidiosis in chickens (broilers –replacement) caused by E.tenella , E.maxima , E.acervulina , E.brunetti and E.necatrix.
Target Species:
Chickens (Broilers –Replacement)
Dosage & route of administration:
Route of administration: Orally with feed
For Active ingredient:
11.35 mg amprolium +0.36 mg ethopabate/ kg.b.wt.
For Whole product:
Broiler Chickens: 454 gm of product / ton medicated feed as sole ration from one day of age until birds are slaughtered.
Replacement Chickens: 454 gm of product / ton medicated feed as sole ration from one day of age until 14 weeks.
Warnings :
• As with any anti parasiticide, frequent and repeated use of antiprotozoals from the same class may lead to the development of resistance.
• Continuous use of Amprolium is resulting into the development of drug resistance which is a major problem and limiting its use. It is rarely used alone because E. maxima and other species are resistant and therefore given in combination with other drugs.
Precautions:
Special precautions for use in animals:
• The product is intended for preventive use.
• Use as sole source of amprolium.
Special precautions to be taken by the person administering the veterinary medicinal product to animals:
• This product is acidic and may cause irritation to, or corrosion of, the skin, eyes,throat and airways.
• Avoid all physical contact with the product, including any vapours.
• Do not eat, drink or smoke whilst handling this product.
• Wear impervious gloves and protective glasses when handling the product.
• In the case of contact with skin or eyes, wash the affected area with clean running water immediately and remove any contaminated clothes. If irritation persists, seek medical advice and show the label to the physician.
• In case of accidental ingestion, rinse the mouth with fresh water, seek medical advice immediately and show the label to the physician
• Those with known hypersensitivity to amprolium or to any of the excipients should avoid contact with the product.
• Wash hands and exposed skin after use.
Use during pregnancy, lactation or lay:
• Studies in laboratory animals have not produced any evidence of teratogenic effects.
• The safety of amprolium has not been investigated in laying birds.
• Use only according to the risk/benefit assessment by the responsible veterinarian.
Contra-indications:
• Do not use in birds producing eggs for human consumption.
• Do not administer to debilitated birds
• Do not use in case of hypersensitivity to the active substance or to any of the excipients.
• Not for chickens over 16 weeks of age
• Do not use amprolium-ethopabate Type C medicated feed as a treatment for outbreaks of coccidiosis.
• Do not change the litter while giving this feed unless absolutely necessary.
• Do not use in feeds containing bentonite.
Drug-drug interactions:
• Amprolium is a thiamine analogue. Therefore, the efficacy of amprolium may be reduced during a simultaneous administration of products containing vitamin B-complex.
• Combination of amprolium with ethopabate, extended and strengthened the spectrum of activity.
Side effect:
• None know.
• Ethopabate is an arylamide containing one phenyl ring, belonging to monocyclic aromatics, is a very safe drug.
• Occasionally may cause GI or neurologic effects.
Poisoning:
• Prolonged uses can produce high thiamine deficiency
Withdrawal Periods:
• Meat :3days
• Do not use in birds producing eggs for human consumption.
Storage:
• Store at temperature not exceed than 30oC
Packaging:
Plastic Jar 100, 250, 500, 1000 gm.
