Solution For Injection

For Veterinary Use Only

Composition:

Each 100 ml contains:
Nitroxynil 34 gm (as Eglumine), Clorsulon 6.7 gm, Ivermectin 0.67 gm

Properties:

Mectonilmart contains (Ivermectin, Clorsulon, Nitroxynil)
Ivermectin is Ivermectin is a broad-spectrum endectocide of the avermectin family.
Ivermectin is a macrocyclic-lactone derivative which has a broad and potent anti parasitic activity against nematodes and arthropods.
Ivermectin acts by inhibiting nerve impulses which binds selectively and with high affinity to glutamate-gated chloride-ion channels which occur in invertebrate nerve and muscle cells. This leads to an increase in the permeability of the cell membrane to chloride ions with hyper polarization of the nerve or muscle cell, resulting in paralysis and death of the relevant parasites. Compounds of this class may also interact with other ligand-gated chloride channels, such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA). The margin of safety for compounds of this class is attributable to the fact that mammals do not have glutamate-gated chloride channels. The macrocyclic lactones have a low affinity for other mammalian ligand-gated chloride channels and they do not readily cross the blood-brain barrier.
Clorsulon is a compound of A benzenesulfonamide family which is recommended for treatment and control of adult forms of Fasciola hepatica & Fasciola gigantic (Liver fluke) in cattle
Clorsulon inhibits glycolytic enzymes of Fasciola hepatica (3-phosphoglycerate kinase and phosphoglyceromutase). This enzymatic inhibition effectively blocks the Embden-Myerhof glycolytic pathway and thereby deprives the fluke of its main source of metabolic energy.
Nitroxynil is a halogenated phenol which is effective against Fasciola hepatica with some activity against gastrointestinal nematodes (Haemonchus contortus). Its mode of action is as an uncoupler of oxidative phosphorylation.
Mectonilmart when used as recommended dose level of
(2 mg Clorsulon/kg b.w., 0.2 mg ivermectin/kg bw, and
10.2 mg nitroxynil/kg bw) it is effective against sensitive strains of the internal and external parasites.

Indications:

Mectonilmart used for :
-The treatment of sensitive gastro-intestinal roundworms, liver flukes ( immature and adult), lungworms, eye worms, sucking and biting lice, mites, screw worm fly and cattle tick.
– Mectonilmart is effective against sensitive strains of the following internal and external parasites:
Internal parasites:
Gastro-intestinal round worm:
Adult and Immature stages of:
Ostertagia ostertagi – (including third and fourth stage larvae and inhibited immatures) Haemonchus placei- Barber’s pole worm- Trichostrongylus axei- Stomach hair worm (including third and fourth stage inhibited larvae)-Trichostrongylus colubriformis – Intestinal hair worm- Ostertagia lyrata – Stomach worm – Cooperia spp- Small intestinal worm (including third and fourth stage inhibited larvae) – Oesophagostomum radiatum
-Nodule worm (including third and fourth stage larvae) – Bunostomum phlebotomum (including third and fourth stage inhibited larvae) and Adult stages of :Whipworm- Trichuris spp – Nematodirus spp – Strongyloides papillosus -Thin necked intestinal worm-Intestinal worm
Immature and adult liver fluke: Fasciola hepatica

Lungworm (adult and immature including inhibited stages):
Dictyocaulus viviparus
Eye worm (adult stages):
Thelazia spp

External parasites:
Sucking Lice:
Haematopinus eurysternus – short nosed sucking louse
Solenopotes capillatus – little blue sucking louse
Linognathus vituli – long nosed sucking louse
Cattle tick: Boophilus microplus
Mites: Sarcoptes scabiei var bovis
Biting lice: Bovicola (Damalinia) bovis
Sustained activity:
Mectonilmart: effectively control infection with Ostertagia spp.and Cooperia spp. acquired up to 7 dayes after treatment and Dictyocaulus viviparous and chrysomya bezziana up to 14 days after treatment.

Target species:

Cattle (Beef and non-lactating dairy cattle)

Dosage & Administration:

Route: subcutaneous injection only (Inject high on the neck behind the ear)
For whole product:
Cattle: 1.5 ml product/50 kg BW

Warning & precautions:

– Sterilize all injection apparatus by boiling (or equivalent) before use.
– Avoid use strong disinfectant on apparatus.
– Maintain cleanliness at all times.
– Keep needle sharp and clean.
– Use shortest needle possible, certainly not exceeding 15mm.
– As far as possible avoid injection of animals during wet weather or under dustily conditions.
– This product should be injected only under the skin.

Contra – Indications:

Do not used intravenously or intramuscularly.
Do not use in cattle which are producing or may in the future produce milk where the milk or milk products may be use for human consumption
Do not re-treat animals for 120 days (4 months) after last treatment.

Adverse Effects:

Transitory discomfort has been observed in some cattle following subcutaneous administration. Soft-tissue swelling and/or slight pain at the injection site has also been observed. These reactions have disappeared without treatment

Withdrawal Time:

Meat : Do not use less than 56 days before slaughter for human consumption.
Milk : Do not use in cattle which are producing or may in the future produce milk where the milk or milk products may be used for human consumption

Storage conditions:

Store at temperature not exceeding 30°C and used immediately after opening

Packaging:

Carton box Containing Amber glass ( Type II ) vials Containing 20,50,100,250,500,1000 ml of Solution closed with bromobutyl rubber stopper and non reusable aluminum closures with an outer label and insert leaflet.