Composition:

Each 1 Liter contains
Oxfendazole 45.3 gm
Triclabendazole 120 gm
Selenium (AS Sodium Selenate) 1.0 gm

Properties:

Otsel is a combind anthelmintic of Oxfendazole , Triclabendazole and Selenium. It used for treatment of benzimidazole-sensitive mature and immature roundworms, lungworms, tapeworms,and early immature ( including 2-week old fluke), immature and mature liver fluke (Fasciola hepatica ) in cattle and sheep.
Triclabendazole is abenzimidazole anthelmintic which acts in of immature and adult fasciola hepatica. It inhibits colchicine binding to microtubular protein suggesting interference of the drug with microtubular structure and function. The drug strongly inhibits the release of proteolytic enzymes in immature and adult parasites, a process dependant on microtubular function.
Oxfendazole is benzimidazole anthelminitic .It possess anti-mitotic properties, and this action is related to their capacity to bind to tubulin leading to inhibition of formation of microtubules. This, in turn, leads to disruption of cell division. Eventually cell lysis and disintegration occur,
It may concentrate preferentially in intestinal cells of parasites to exert its toxic effects initially and principally at this site.
Selenium is as a component of the enzyme glutathione peroxidase (GSH-PX). The exact role of GSH-PX in mammalian cells is not fully understood but it is thought to act by protecting cells from oxidizing agents which are capable of irreversibly denaturing essential cellular proteins which leads to degeneration and necrosis, resulting in muscular weakness and white muscle disease commonly associated with selenium deficiency. It is believed that a deficiency in selenium can cause a decrease in the humoral response of animals to vaccination and increase the susceptibility of animals to disease. The symptoms are most pronounced in young fast growing animals.

Indications:

For treatment of:
Benzimidazole -sensitive mature and immature roundworms, lungworms, tapeworms and early immature (including 2-week old fluke), immature and mature liver fluke (Fasciola hepatica) in cattle and sheep.
Cattle: (Haemonchus placei) Barber’s pole worm; (Trichostrongylus axei) Stomach
hair worm; (Ostertagia ostertagi) Small brown stomach worm including inhibited (hypobiotic) stages; (Trichostrongylus spp) Black scour worm; (Cooperia spp) Small intestinal worm; (Nematodirus spp) Thin necked intestinal worm; (Oesophagostomum radiatum) Nodule worm; (Dictyocaulus viviparus) Large lungworm; (Moniezia spp) Tapeworm; (Fasciola hepatica) Early immature (including 2-week old fluke), immature and mature liver fluke.
Sheep: (Haemonchus contortus) Barber’s pole worm; (Trichostrongylus axei) Stomach hair worm; (Ostertagia [Teladorsagia] spp) Small brown stomach worm; (Trichostrongylus spp) Black scour worm; (Cooperia spp) Small intestinal worm; (Nematodirus spp) Thin necked intestinal worm; (Oesophagostomum columbianum) Nodule worm; (Oesophagostomum venulosum) Large bowel worm; (Chabertia ovina) Large mouthed bowel worm; (Dictyocaulus filaria) Large lungworm; (Moniezia expansa) Tapeworm; (Fasciola hepatica) Early immature (including 2-week old fluke), immature and mature liver fluke.

Target Species:

Cattle and sheep

Dosage & Route of administration:

Shake well before use
Route: orally
For whole product:
5ml of product /50 kg.b.wt.

Warnings:

-Care should be taken when dosing animals to avoid causing injury to the mouth and pharynx.
-The use of this product may have harmful effects on fish and aquatic invertebrates.
– Cattle and sheep must not have any access to the surface water such as streams, ponds or ditches within 7 days after treatment. When spreading manure from treated animals on arable lands, a safety distance of 10m to adjacent surface waters must be kept.
-Equipment should be thoroughly cleaned before and after dosing.
-Do not exceed the stated dose.
-This product should not be used when selenium intake from pasture is high or selenium is provided by other means (such as pasture top dressing, vaccine, pellets or selenium drenches) or if blood selenium levels at treatment are high.
-Users can determine selenium status by consulting their veterinarian

Contra-indications:

-Do not use in animals which are producing milk or milk products for human consumption.
-Do not use less than 21 days before calving in cows or lambing in ewes where milk and milk products from treated animals may be used for human consumption.
-Calves fed this milk should not be slaughtered for human consumption within 10 days. Lambs fed this milk should not be slaughtered for human consumption within 7 days.

Adverse effects :

-Occasionally, inflammation of the un pigmented skin, including the udder and the teats may occur after treatment in cattle exposed to intense sunshine.

Withdrawal Periods:

-Cattle: 56 days . – Sheep: 63 days .

Storage conditions:

Store at temperature not exceeding 30°C.

Packaging:

100, 250, 500 and 1000 ml of the product in white (HDPE) plastic bottle closed by opaque (HDPE) white screw cap lined with (HDPE) plastic film with an outer Label.