Composition:

Each 1ml contains:
Fenbendazole.           50 mg
Rafoxanide                50 mg

Properties:

Fenbendazole is a benzimidazoles anthelmintic. It blocks fumarate reductase, which results in the inhibition of the formation of adenosine triphosphate (involved in mitochondrial energy). There is also evidence that it inhibits glucose uptake and therefore increases glycogen utilization and depletes the worm’s glycogen reserves.

The overall effect of this action is to effectively starve the parasite to death. Furthermore, this action results in the detachment of the parasites, but in the case of intestinal helminthes, this detachment does not result in loss of contact with the drug, whereas in the case of the liver fluke, such detachment would reduce such contact. This probably explains its limited effect on the liver fluke and the good effect on intestinal helminths. the Rafoxanide is a salicylanilides flukicide  anthelmintic. Rafoxanide uncouple oxidative phosphorylation in Fasciola hepatica and other parasites Fenbendazole is absorbed poorly from the gastro-intestinal tract leading to low plasma levels of Fenbendazole, Oxfendazole and Sulphone. It is mainly excreted in the faeces though some of the metabolites that have been identified are excreted in the urine and bile The active and its metabolites are mainly found in the plasma.

Indications:

The product permits a three-way activity against Fluke, Lungworms and Stomach worms in cattle and sheep.

It is a broad spectrum anthelmintic for the treatment of benzimidazole-susceptible mature and immature stages of nematodes and cestodes of the gastrointestinal and respiratory tracts of cattle and sheep.

The product is active against:

Haemonchus sp.

Ostertagia sp.

Trichostrongylus sp.

Cooperia sp.

Nematodirus sp.

Bunostomum sp.

Trichuris sp.

Strongyloides sp.

Oesophagostomum sp.

Dictyocaulus sp.

Moniezia sp.

Immature and mature Fasciola sp. over 8 weeks of age.

The product has a good therapeutic effect against type II Ostertagiasis.

Target Species:

Cattle and sheep.

Dosage & route of administration:

Route of administration: oral administration

– Shake well before use.

-For whole product: – (Sheep): 1.5 ml / 10 kg .b.wt. At 2 months after housing,

                                       (Cattle): 11.25 ml of product / 50 kg.b.wt. At 2 months after housing

-when dosing cattle for worms and adult fluke, a lower dose of 7.5 mg/kg can be used i.e. 7.5 ml /50kg .b.wt, 30 ml /200kg or 75 ml / 500kg.

Warnings:

-Veterinary advice should be sought on appropriate dosing programs and stock management to achieve adequate parasite control and reduce the likelihood of anthelmintic resistance developing.

-Where a dosing gun is used to administer the product, care should be taken to avoid causing injury to the mouth and pharynx of animals. Resistance developing is consumed within 24 hours.

– Rinse splashes into the eyes with water immediately.

-Wash hands after use.

– Fenbendazole and Rafoxanide are safe for use during pregnancy.

Contra-indication:

-Not authorized for use in animals producing milk for human consumption including during the dry period.

– Do not use during the last trimester of pregnancy in heifers which are intended to produce milk for human consumption.

-Do not use within 1 year prior to the first lambing in ewes intended to produce milk for human consumption.

Side effects:

None known.

Withdrawal Period:

Meat: 60 days

Milk:

Not authorized for use in animals producing milk for human consumption including during the dry period

Storage conditions:

Store in temperature not exceed 30 ᵒC.

Packagings:

Opaque white (HDPE) plastic bottle contain 20, 25, 50, 75, 100, 200,250,500, 750, 1000 ml Oral suspension lined with red (HDPE) plastic film and aluminum sealed closed by white Plastic (HDPE) cap with (LDPE) inner foam liner with an outer label without insert.