Composition :

Each 1 gm contains :
Colistin ( as Sulfate ) 750 000 IU

Properties:

Colistin is a polypeptide antibiotic belonging to the class of polymyxins.
Colistin has bactericidal action on sensitive bacterial strains, by disorganization of their cytoplasmic membrane, leading to an alteration of the cell permeability and thus to a loss of intracellular material. Colistin has a bactericidal powder against a broad spectrum of Gram-negative bacteria, including Enterobacteriaceae and in particular Escherichia coli. Colistin has very little activity against Gram-positive bacterial and fungal organisms.
Gram-positive bacteria, as well as some species of Gram-negative bacteria such as Proteus and Serratia, are naturally resistant to colistin. However, the acquisition of resistance of gram-negative enteric bacteria to colistin is rare and can be explained by simple mutation.
Colistin exhibits concentration-dependent activity against Gram-negative bacteria. Following oral administration, high concentrations are observed in the gastrointestinal tract, i.e., the target site, due to the low absorption of the substance.

Indications:

• Treatment and metaphylaxis of gastrointestinal infections due to non-invasive colistin-sensitive E.coli.
• The presence of the disease in the flock must be established before proceeding to metaphylactic treatm ent.

Target Species:

Calves, lambs, pigs, rabbits, poultry.

Dosage & route of administration:

Taken orally in milk or drinking water
For whole product:
– Calves, lambs, pigs, rabbits: 1.3 g of powder / 10 kg .b.wt./ day in two equal doses for 3-7 days.
– Poultry: 1gm / 10 kg.b.wt. / day orally in drinking water for 3 days; or 100 grams of powder /ton of live weight / day for 3-7 days.
– Duration of treatment should be limited to the minimum time necessary for the treatment of the disease.
– Treatment duration should not exceed 7 days

Warnings :

special warnings for each target species:
• Colistin exerts concentration-dependent activity against Gram-negative bacteria. Following oral administration, high concentrations are achieved in the gastrointestinal tract, i.e., the target site, due to the poor absorption of the substance. These factors indicate that a longer duration of treatment than one indicated in dosage section leading to unnecessary exposure, is not recommended.
Special precautions for use in animals:
• Do not use colistin as a substitute for good management practices
• Colistin is a last resort in human medicine for the treatment of infections caused by certain multi drug-resistant bacteria. In order to minimize any potential risk associated with widespread use of colistin, its use should be limited to treatment or treatment and metaphylaxis of diseases, and should not be used in prophylaxis.
• Whenever possible. colistin should only be used based on susceptibility testing.
• Use of the product deviating from the instruction given in the insert may lead to treatment failure and increase the prevalence of bacteria resistant to colistin

Withdrawal Periods:

Calves, lambs, pigs, rabbits, poultry ( Meat and offal) : 7 days
Poultry( Eggs): Zero hours

Contra-indications:

Do not use in horses, particularly in foals, since colistin, due to a shift in the gastrointestinal microflora balance could lead to the development of antimicrobial associated colitis (Colitis X), typically associated with Clostridium difficile, which may be fatal.

Storage:

Store at temperature not exceeding 30°C, used immediately after opening and reconstitution.

Packaging:

( HDPE) white plastic jar contains transparent plastic ( LDPE) bag containing 100, 250, 500 and 1000 gm of the product with ( HDPE) white plastic cap with an outer label without Insert.