Germsulfa
Neocleer
(W.S.P)
(For Vet Use Only)
Composition :
Each 1gm contains:
Amprolium HCL 240 mg
(Eq. to amprolium base 212.2 mg )
Properties:
Amprolium is an anticoccidial agent that acts as competitive inhibitor of thiamine in the parasite metabolism, and interferes with the metabolism of glucides necessaries for coccidian multiplication and survival.
In in-vitro studies it was shown that the uptake of thiamine by schizonts of Eimeria tenella and by host intestinal cells can occur through passive diffusion or by an active, energy-and ph-dependent process. Amprolium competitively inhibited both systems; however, the parasite was shown to be more sensitive to amprolium than the host.
As shown with Eimeria maxima inoculated chicken, the administration of Amprolium resulted in a proportion of morphologically abnormal macrogametes and oocysts which may be considered the reason for a reduced sporulation rate.
Contra-indications
- The product is not intended for a preventive use.
- Treatment is usually no longer than 14 days.
Side-Effects:
- Studies in laboratory animals have not produced any evidence of teratogenic effects. The safety of amprolium has not been investigated in laying birds. Use only according to the risk/benefit assessment by the responsible veterinarian.
- Prolonged uses can produce thiamine deficiencies.
- Should symptoms appear, thiamine must be administered
Withdrawal Periods:
Chickens and turkeys:
Meat and offal’s : zero days
Eggs : zero days
Storage conditions:
- Store at room temperature.
- Kept away from direct sunlight.
- Kept away from reach of children.
Packaging:
Plastic containers: 100, 500 and 1000 gram plastic jars.
Indications:
Treatment of:
Chickens (broilers, pullets, laying and breeding hens) coccidiosis caused by: E.tenella, E.necatrix, E.acervulina, E.brunetti, E.maxima and E.mitis
Turkeys: coccidiosis caused by: E.adenoides, E.dispersa, E.gallopavonis, E.meleagrimitis, E.innocua, E.meleagridis, and E.subrotunda.
Target Species:
Chickens (broilers, pullets, laying and breeding hens) and turkeys
Dosage& route of administration:
Orally via drinking water.
For active ingredient:
20 mg Amprolium / 1 kg. b.wt
Dose for whole product:
1gm of product/liter of drinking water for 5-7 days.
Warnings & precautions:
- This product should be reserved in case of coccidiosis outbreaks due to non-availability of vaccine, in case of lack of efficacy of vaccine and in vaccinated flocks if a severe coccidial challenge is diagnosed before immunity has fully developed.
- Amprolium is a thiamine analogue. Therefore, the efficacy of amprolium may be reduced during a simultaneous administration of products containing vitamin B-complex.
- Should Wear impervious gloves and protective glasses when handling the
- Should Avoid contact with the skin and eyes
