Composition:

Each 1 gm contains:
Valnemulin hydrochloride 532.5 mg (eq. to valnemulin base 500 mg)

Properties:

Valnemulin is an antibiotic belonging to the pleuromutilin group, which acts by the inhibition of the initiation of protein synthesis at the level of the bacterial ribosome. Valnemulin has activity aiainst a range of bacteria including those responsible for enteric and respiratory disease in pigs. Valnemulin shows high activity against Mycoplasma spp and Spirochaetes such as Brachyspira hyodysenteriae and Brachyspira pilosicoli in swine. Clostridium perfringens, a bacterium which may be involved in rhe development of ERE. Valnemulin has little activity against Enterobacteriaceae, such as Salmonella spp and Escherichia coli.

Indications:

• Treatment of swine dysentery which caused by Brachspira hyodysenteriae.
• Treatment of clinical signs of porcine proliferative enteropathy (ileitis) which caused by lawsonia intracellularis.
• Treatment of swine enzootic pneumonia which caused by Mycoplasma hyopneumoniae.

Target Species:

Pigs.

Dosage & route of administration:

Route: Route: Orally with feed.

For Active Ingredient:
• Treatment of swine dysentery: 4 mg valnemulin / kg b.wt / day for a minimum of7 days and up to 4 weeks, or until signs of disease disappear.
• Treatment of porcine proliferative enteropathy: 4 mg valnemulin / kg b. wt/ day for 2 weeks or until signs of disease disappear.
• Treatment of swine enzootic pneumonia: 12 mg valnemulin / kg b.wt / day for up to 3 weeks.

For whole product:
• Treatment of swine dysentery: 80 gm of product/ ton feed for a minimum of 7 days and up to 4 weeks or until signs disappear.
T• reatment of porcine proliferavtive enteropathy (ileitis): 80 g of product / ton feed for 2 weeks or until signs of disease disappear
• Treatment of swine enzootic pneumonia : 240 gm of product/ ton feed for up to 3 weeks.

Warnings:

• When treating infections caused by Brachyspira spp therapy should be based on local (regional farm level) epidemiological information about susceptibility of the target bacteria.
• Valnemulin has been shown to interact with ionophores such as monensin, salinomycin and narasin and may result in signs indistinguishable from an ionophoretoxicosis.
• Animals should not receive veterinary medicinal products containing monensin, salinomycin or narasin, during or at least 5 days before or after treatment with valnemulin. Severe growth depression, ataxia, paralysis or death may result.
  

Contra-indication:

•Animais should not receive products containing monensin, salinonycin or narasin, during or at least 5 days before or after treatment with valnemulin. Sever growth depression, ataxia, paralysis or death may result.

Side effects:

• Most common adverse reactions observed in these pigs are pyrexia, anorexia and in severe cases a axia and recumbency.
• A perfentage of such pigs may also suffer oedema or erythema (posterior in distribution), and palpebral oedema.

Withdrawal Period(s):

Pigs: Meat and offal: I day.

Storage conditions:

• Store at temperature not more than 30°C
• Used immediately after opening & after reconstitution.
• Keep out from reach of children.

Packagings:

100,250,500 and1000 gm plastic jar.